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Nanoparticles

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Computational biology and artificial intelligence in mRNA vaccine design for cancer immunotherapy.

Frontiers in cellular and infection microbiology
Messenger RNA (mRNA) vaccines offer an adaptable and scalable platform for cancer immunotherapy, requiring optimal design to elicit a robust and targeted immune response. Recent advancements in bioinformatics and artificial intelligence (AI) have sig...

Application of supervised learning models for enhanced lead (II) removal from wastewater via modified cellulose nanocrystals (CNCs).

Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering
Heavy metal ions are acknowledged to impact the environment and human health adversely. CNCs are effective materials for removing heavy metal ions in industrial applications and process innovations since they can be used in static and dynamic adsorpt...

Advancements and Prospects in Nanorobotic Applications for Ophthalmic Therapy.

ACS biomaterials science & engineering
This study provides a bibliometric and bibliographic review of emerging applications of micro- and nanotechnology in treating ocular diseases, with a primary focus on glaucoma. We aim to identify key research trends and analyze advancements in device...

"Three-in-one" Analysis of Proteinuria for Disease Diagnosis through Multifunctional Nanoparticles and Machine Learning.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Urinalysis is one of the predominant tools for clinical testing owing to the abundant composition, sufficient volume, and non-invasive acquisition of urine. As a critical component of routine urinalysis, urine protein testing measures the levels and ...

Optimizing thermal dose prediction in nanoparticle-mediated photothermal therapy using a convolutional neural network-based model.

Journal of thermal biology
Nanoparticle-mediated photothermal therapy (NMPTT) is an up-and-coming targeted cancer treatment. Here, nanoparticles are used to convert near-infrared light into localized heat that can kill tumour cells while sparing surrounding healthy tissue. Nev...

High throughput analysis of rare nanoparticles with deep-enhanced sensitivity via unsupervised denoising.

Nature communications
The large-scale multiparametric analysis of individual nanoparticles is increasingly vital in the diverse fields of biology, medicine, and materials science. However, the current methods struggle with the tradeoff between measurement scalability and ...

Revolutionizing prostate cancer therapy: Artificial intelligence - Based nanocarriers for precision diagnosis and treatment.

Critical reviews in oncology/hematology
Prostate cancer is one of the major health challenges in the world and needs novel therapeutic approaches to overcome the limitations of conventional treatment. This review delineates the transformative potential of artificial intelligence (AL) in en...

Machine learning integrated with in vitro experiments for study of drug release from PLGA nanoparticles.

Scientific reports
This paper investigates delivery of encapsulated drug from poly lactic-co-glycolic micro-/nano-particles. Experimental data collected from about 50 papers are analyzed by machine learning algorithms including linear regression, principal component an...

Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke.

ACS nano
Small interfering RNA (siRNA) targeting the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has emerged as a promising therapeutic strategy to mitigate infarct volume and brain injury following ischemic stroke. However, the cl...

Machine learning-assisted design of immunomodulatory lipid nanoparticles for delivery of mRNA to repolarize hyperactivated microglia.

Drug delivery
Regulating inflammatory microglia presents a promising strategy for treating neurodegenerative and autoimmune disorders, yet effective therapeutic agents delivery to these cells remains a challenge. This study investigates modified lipid nanoparticle...