Regulating inflammatory microglia presents a promising strategy for treating neurodegenerative and autoimmune disorders, yet effective therapeutic agents delivery to these cells remains a challenge. This study investigates modified lipid nanoparticle...
International journal of pharmaceutics
Nov 10, 2025
Vaccines have long been crucial in safeguarding public health by preventing and controlling infectious diseases. However, traditional vaccine development methods face challenges in efficiency, cost, and response time to emerging pathogens. Recent pro...
Nanoplastics (NPs) are widespread in ecosystems, and their biohazards are of increasing concern. The hazards posed by NPs to aquatic and terrestrial plants as well as to aquatic animals have been extensively studied; however, their impact on mammals ...
Journal of controlled release : official journal of the Controlled Release Society
Aug 10, 2025
Flumist is the only FDA-approved intranasal influenza vaccine. Although it has recently been approved for at-home use, it has significant limitations. These include reduced effectiveness in generating a protective immune response in patients with ext...
: Early detection of oncological diseases such as pancreatic ductal adenocarcinoma (PDAC) and ovarian cancer (OV) is pivotal for successful treatment but remains a significant challenge due to the lack of sensitive and specific diagnostic tests. Fluo...
Emerging pollutants such as tetracycline antibiotics (TCs) have garnered attention due to their ecological impacts and the evolution of drug resistance. However, the comprehensive monitoring of TCs remains inadequate. This study presents a multifunct...
Ecotoxicology and environmental safety
Jul 1, 2025
This study presents a comprehensive machine learning-driven analysis to understand and predict the toxicity of nanoparticles (NPs), a crucial aspect in ensuring the safe application of nanotechnology in medicine, pharmaceuticals, biotechnology, and v...
Extracellular vesicles (EVs), which are secreted by various cell types, hold significant potential for cancer therapy. However, there are several challenges and difficulties that limit their application in clinical settings. This review, which integr...
RNA interference (RNAi) has emerged as a transformative approach for cancer therapy, enabling precise gene silencing through small interfering RNA (siRNA). However, the clinical application of siRNA-based treatments faces challenges such as rapid deg...
Carbon dots (CDs) are emerging as next-generation bioimaging agents due to their strong fluorescence, photobleaching resistance, and biocompatibility. However, their small size often limits efficient cell internalization, leading to unspecified cellu...
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