AIMC Topic: Neoadjuvant Therapy

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Self-supervised network predicting neoadjuvant chemoradiotherapy response to locally advanced rectal cancer patients.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Radiographic imaging is a non-invasive technique of considerable importance for evaluating tumor treatment response. However, redundancy in CT data and the lack of labeled data make it challenging to accurately assess the response of locally advanced...

Integrating Machine Learning and Bulk and Single-Cell RNA Sequencing to Decipher Diverse Cell Death Patterns for Predicting the Prognosis of Neoadjuvant Chemotherapy in Breast Cancer.

International journal of molecular sciences
Breast cancer (BRCA) continues to pose a serious risk to women's health worldwide. Neoadjuvant chemotherapy (NAC) is a critical treatment strategy. Nevertheless, the heterogeneity in treatment outcomes necessitates the identification of reliable biom...

MRI radiomics combined with delta-radiomics model for predicting pathological complete response in locally advanced rectal cancer patients after neoadjuvant chemoradiotherapy: A multi-institutional study.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
PURPOSE: To construct and validate a magnetic resonance imaging (MRI) radiomics combined with delta-radiomics and clinical information (C) model for predicting pathological complete response (pCR) in patients with locally advanced rectal cancer (LARC...

Early prediction of neoadjuvant therapy response in breast cancer using MRI-based neural networks: data from the ACRIN 6698 trial and a prospective Chinese cohort.

Breast cancer research : BCR
BACKGROUND: Early prediction of treatment response to neoadjuvant therapy (NAT) in breast cancer patients can facilitate timely adjustment of treatment regimens. We aimed to develop and validate a MRI-based enhanced self-attention network (MESN) for ...

Multimodal diagnostic models and subtype analysis for neoadjuvant therapy in breast cancer.

Frontiers in immunology
BACKGROUND: Breast cancer, a heterogeneous malignancy, comprises multiple subtypes and poses a substantial threat to women's health globally. Neoadjuvant therapy (NAT), administered prior to surgery, is integral to breast cancer treatment strategies....

Voxel-level radiomics and deep learning for predicting pathologic complete response in esophageal squamous cell carcinoma after neoadjuvant immunotherapy and chemotherapy.

Journal for immunotherapy of cancer
BACKGROUND: Accurate prediction of pathologic complete response (pCR) following neoadjuvant immunotherapy combined with chemotherapy (nICT) is crucial for tailoring patient care in esophageal squamous cell carcinoma (ESCC). This study aimed to develo...

Prediction of Chemotherapy Response in Locally Advanced Breast Cancer Patients at Pre-Treatment Using CT Textural Features and Machine Learning: Comparison of Feature Selection Methods.

Tomography (Ann Arbor, Mich.)
RATIONALE: Neoadjuvant chemotherapy (NAC) is a key element of treatment for locally advanced breast cancer (LABC). Predicting the response of NAC for patients with LABC before initiating treatment would be valuable to customize therapies and ensure t...

Prognostic model for log odds of negative lymph node in locally advanced rectal cancer via interpretable machine learning.

Scientific reports
No studies have examined the prognostic value of the log odds of negative lymph nodes/T stage (LONT) in locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiotherapy (nCRT). We aimed to assess the prognostic value of LONT and devel...

Enhancing the role of MRI in rectal cancer: advances from staging to prognosis prediction.

European radiology
Rectal cancer (RC) is one of the major health challenges worldwide. Accurate staging, restaging, invasiveness assessment, and treatment efficacy evaluation are crucial for its clinical management. Magnetic resonance imaging (MRI) plays a significant ...