AIMC Topic: Phenotype

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An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism.

Scientific reports Jul 7, 2021
Venous thromboembolism is the third common cardiovascular disease and is composed of two entities, deep vein thrombosis (DVT) and its potential fatal form, pulmonary embolism (PE). While PE is observed in ~ 40% of patients with documented DVT, there ...
Genetic Predisposition to Disease Polymorphism, Single Nucleotide Proteomics Humans Adult Neural Networks, Computer Male Genome-Wide Association Study COVID-19 Phenotype Female Pulmonary Embolism Receptors, Cell Surface
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Active and machine learning-based approaches to rapidly enhance microbial chemical production.

Metabolic engineering Jul 3, 2021
In order to make renewable fuels and chemicals from microbes, new methods are required to engineer microbes more intelligently. Computational approaches, to engineer strains for enhanced chemical production typically rely on detailed mechanistic mode...
Phenotype Escherichia coli Metabolic Engineering Machine Learning
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Automated Detection and Diameter Estimation for Mouse Mesenteric Artery Using Semantic Segmentation.

Journal of vascular research Jun 28, 2021
BACKGROUND: Pressurized myography is useful for the assessment of small artery structures and function. However, this procedure requires technical expertise for sample preparation and effort to choose an appropriate sized artery. In this study, we de...
Mice, Transgenic Myography Male Mesenteric Arteries Mesenteric Veins Mice, Inbred C57BL Image Interpretation, Computer-Assisted Phenotype Mice Neural Networks, Computer Female Genotype Animals Machine Learning Automation Predictive Value of Tests Arterial Pressure Microscopy
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Review: Application of Artificial Intelligence in Phenomics.

Sensors (Basel, Switzerland) Jun 25, 2021
Plant phenomics has been rapidly advancing over the past few years. This advancement is attributed to the increased innovation and availability of new technologies which can enable the high-throughput phenotyping of complex plant traits. The applicat...
Phenomics Machine Learning Software Phenotype Artificial Intelligence
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Emerging machine learning approaches to phenotyping cellular motility and morphodynamics.

Physical biology Jun 17, 2021
Cells respond heterogeneously to molecular and environmental perturbations. Phenotypic heterogeneity, wherein multiple phenotypes coexist in the same conditions, presents challenges when interpreting the observed heterogeneity. Advances in live cell ...
Machine Learning Phenotype Cell Movement Physiology
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Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning.

eLife Jun 15, 2021
Cardiometabolic diseases are an increasing global health burden. While socioeconomic, environmental, behavioural, and genetic risk factors have been identified, a better understanding of the underlying mechanisms is required to develop more effective...
Digestive System Iron Body Composition Deep Learning Image Processing, Computer-Assisted Abdomen Models, Genetic Magnetic Resonance Imaging Adipose Tissue Aged Humans Male Phenotype Middle Aged Female
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Phenotyping the Spectrum of Traumatic Brain Injury: A Review and Pathway to Standardization.

Journal of neurotrauma Jun 10, 2021
It is widely appreciated that the spectrum of traumatic brain injury (TBI), mild through severe, contains distinct clinical presentations, variably referred to as subtypes, phenotypes, and/or clinical profiles. As part of the Brain Trauma Blueprint T...
Reference Standards Machine Learning Humans Phenotype Brain Injuries, Traumatic
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Leveraging Machine Learning and Artificial Intelligence to Improve Peripheral Artery Disease Detection, Treatment, and Outcomes.

Circulation research Jun 10, 2021
Peripheral artery disease is an atherosclerotic disorder which, when present, portends poor patient outcomes. Low diagnosis rates perpetuate poor management, leading to limb loss and excess rates of cardiovascular morbidity and death. Machine learnin...
Atherosclerosis Supervised Machine Learning Image Interpretation, Computer-Assisted Treatment Outcome Peripheral Arterial Disease Natural Language Processing Carotid Artery Diseases Life Style Aortic Aneurysm Behavior Therapy Machine Learning Algorithms Forecasting Phenotype Humans Prognosis Artificial Intelligence Risk Assessment
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Convolutional Neural Networks to Estimate Dry Matter Yield in a Guineagrass Breeding Program Using UAV Remote Sensing.

Sensors (Basel, Switzerland) Jun 9, 2021
Forage dry matter is the main source of nutrients in the diet of ruminant animals. Thus, this trait is evaluated in most forage breeding programs with the objective of increasing the yield. Novel solutions combining unmanned aerial vehicles (UAVs) an...
Remote Sensing Technology Animals Brazil Cattle Neural Networks, Computer Phenotype
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Development and application of the ocular immune-mediated inflammatory diseases ontology enhanced with synonyms from online patient support forum conversation.

Computers in biology and medicine Jun 8, 2021
BACKGROUND: Unstructured text created by patients represents a rich, but relatively inaccessible resource for advancing patient-centred care. This study aimed to develop an ontology for ocular immune-mediated inflammatory diseases (OcIMIDo), as a too...
Humans Phenotype Databases, Factual Language Biological Ontologies
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