AIMC Topic: Precision Medicine
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Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis.
Nature communications
Jul 2, 2025
Approximately 40% of patients with rheumatoid arthritis do not respond to individual biologic therapies, while biomarkers predictive of treatment response are lacking. Here we analyse RNA-sequencing (RNA-Seq) of pre-treatment synovial tissue from the...
Knee injury prevention via personalized exercise using EDAS method and Sugeno Weber operator under complex q rung orthopair fuzzy data.
Scientific reports
Jul 2, 2025
Knee injuries are common in several people, frequently controlling for significant injuries and health care costs. This article explains the role of personalized exercise prescriptions in preventing knee injuries. For this purpose, we used the multic...
A genotype-to-drug diffusion model for generation of tailored anti-cancer small molecules.
Nature communications
Jul 1, 2025
Despite advances in precision oncology, developing effective cancer therapeutics remains a significant challenge due to tumor heterogeneity and the limited availability of well-defined drug targets. Recent progress in generative artificial intelligen...
Personalized azithromycin treatment rules for children with watery diarrhea using machine learning.
Nature communications
Jul 1, 2025
We use machine learning to identify innovative strategies to target azithromycin to the children with watery diarrhea who are most likely to benefit. Using data from a randomized trial of azithromycin for watery diarrhea (NCT03130114), we develop per...
Harnessing the machine learning and nomogram models: elevating prognostication in nonmetastatic gastric cancer with "double invasion" for personalized patient care.
European journal of medical research
Jun 23, 2025
OBJECTIVE: To develop and validate a machine learning framework combined with a nomogram for predicting recurrence after radical gastrectomy in patients with vascular and neural invasion.
Artificial Intelligence in cancer epigenomics: a review on advances in pan-cancer detection and precision medicine.
Epigenetics & chromatin
Jun 14, 2025
DNA methylation is a fundamental epigenetic modification that regulates gene expression and maintains genomic stability. Consequently, DNA methylation remains a key biomarker in cancer research, playing a vital role in diagnosis, prognosis, and tailo...
The Role of Artificial Intelligence Large Language Models in Personalized Rehabilitation Programs for Knee Osteoarthritis: An Observational Study.
Journal of medical systems
Jun 3, 2025
BACKGROUND: Large language models (LLMs) can contribute to treatment options and outcomes by assisting physiotherapists for conditions like osteoarthritis.
AI-Driven Biomarker Discovery and Personalized Allergy Treatment: Utilizing Machine Learning and NGS.
Current allergy and asthma reports
Jun 3, 2025
PURPOSE OF REVIEW: This review explores the transformative potential of artificial intelligence (AI) and next-generation sequencing (NGS) in allergy diagnostics and treatment. It focuses on leveraging these technologies to enhance precision in biomar...
Current AI technologies in cancer diagnostics and treatment.
Molecular cancer
Jun 2, 2025
Cancer continues to be a significant international health issue, which demands the invention of new methods for early detection, precise diagnoses, and personalized treatments. Artificial intelligence (AI) has rapidly become a groundbreaking componen...
From Molecular Precision to Clinical Practice: A Comprehensive Review of Bispecific and Trispecific Antibodies in Hematologic Malignancies.
International journal of molecular sciences
Jun 1, 2025
Multispecific antibodies have redefined the immunotherapeutic landscape in hematologic malignancies. Bispecific antibodies (BsAbs), which redirect cytotoxic T cells toward malignant targets via dual antigen engagement, are now established components ...
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