BACKGROUND: Programmed cell death (PCD) refers to a regulated and active process of cellular demise, initiated by specific biological signals. PCD plays a crucial role in the development, progression, and drug resistance of uterine corpus endometrial...
We consider the problem of renal mass risk classification to support doctors in adjuvant treatment decisions following nephrectomy. Recommendation of adjuvant therapy based on the mass appearance poses two major challenges: first, morphologic pattern...
OBJECTIVE: The objective of this study is to compare the clinical features and survival outcomes of class IV ± V lupus nephritis (LN) patients, identify risk factors, and develop an accurate prognostic model.
BACKGROUND: Triple-negative breast cancer (TNBC) is a highly aggressive subtype with limited therapeutic targets and poor immunotherapy outcomes. The tumor microenvironment (TME) plays a key role in cancer progression. Advances in single-cell transcr...
BACKGROUND: Colorectal cancer (CRC) is one of the leading contributors to cancer-related deaths worldwide, with more than 900,000 new diagnoses and related deaths each year. This study aims to explore the prognostic value of tumor-infiltrating immune...
BACKGROUND: Acute Myeloid Leukemia (AML) exhibits significant heterogeneity in clinical outcomes, yet current prognostic stratification systems based on genetic alterations alone cannot fully capture this complexity. This study aimed to develop an in...
OBJECTIVE: To develop and validate an interpretable machine learning (ML) model for the preoperative prediction of central lymph node metastasis (CLNM) in papillary thyroid microcarcinoma (PTMC).
INTRODUCTION: Tuberculous meningitis (TBM) leads to high mortality, especially amongst individuals with HIV. Predicting the incidence of disease-related complications is challenging, for which purpose the value of brain magnetic resonance imaging (MR...
BACKGROUND: Breast cancer is a heterogeneous malignancy with complex molecular characteristics, making accurate prognostication and treatment stratification particularly challenging. Emerging evidence suggests that lactylation, a novel post-translati...
BACKGROUND: Lung adenocarcinoma (LUAD) is a major cause of cancer mortality. Considering the critical role of tumor infiltrating lymphocytes in effective immunotherapy, this study was designed to screen molecular markers related to tumor infiltrating...
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