AIMC Topic: Proof of Concept Study

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Non-invasive diagnosis of non-alcoholic steatohepatitis and fibrosis with the use of omics and supervised learning: A proof of concept study.

Metabolism: clinical and experimental
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) affects 25-30% of the general population and is characterized by the presence of non-alcoholic fatty liver (NAFL) that can progress to non-alcoholic steatohepatitis (NASH), liver fibrosis and cirr...

The hidden information in patient-reported outcomes and clinician-assessed outcomes: multiple sclerosis as a proof of concept of a machine learning approach.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Machine learning (ML) applied to patient-reported (PROs) and clinical-assessed outcomes (CAOs) could favour a more predictive and personalized medicine. Our aim was to confirm the important role of applying ML to PROs and CAOs of people with relapsin...

Towards early monitoring of chemotherapy-induced drug resistance based on single cell metabolomics: Combining single-probe mass spectrometry with machine learning.

Analytica chimica acta
Despite the presence of methods evaluating drug resistance during chemotherapies, techniques, which allow for monitoring the degree of drug resistance in early chemotherapeutic stage from single cells in their native microenvironment, are still absen...

Bio-inspired robotic dog paddling: kinematic and hydro-dynamic analysis.

Bioinspiration & biomimetics
Research on quadrupedal robots inspired by canids or felids have been widely reported and demonstrated. However, none of these legged robots can deal with difficult environments that include water, such as small lakes, streams, rain, mud, flooded ter...

Pushing the Boundaries of Molecular Representation for Drug Discovery with the Graph Attention Mechanism.

Journal of medicinal chemistry
Hunting for chemicals with favorable pharmacological, toxicological, and pharmacokinetic properties remains a formidable challenge for drug discovery. Deep learning provides us with powerful tools to build predictive models that are appropriate for t...

Use of Natural Language Processing Tools to Identify and Classify Periprosthetic Femur Fractures.

The Journal of arthroplasty
BACKGROUND: Manual chart review is labor-intensive and requires specialized knowledge possessed by highly trained medical professionals. The cost and infrastructure challenges required to implement this is prohibitive for most hospitals. Natural lang...

Development and Evaluation of ClientBot: Patient-Like Conversational Agent to Train Basic Counseling Skills.

Journal of medical Internet research
BACKGROUND: Training therapists is both expensive and time-consuming. Degree-based training can require tens of thousands of dollars and hundreds of hours of expert instruction. Counseling skills practice often involves role-plays, standardized patie...