AIMC Topic: Proof of Concept Study

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Vibe Coding in nephrology education: clinician-led, AI-assisted development of open-source interactive learning tools.

Renal failure
Medical education increasingly incorporates digital technologies; however, many tools remain passive and text-based. is a clinician-led design framework that embeds expert reasoning and the cognitive 'feel' of clinical decision-making into interacti...

Exploring synthetic controls in rare diseases with a proof of concept in spinal cord injury.

BMC medicine
BACKGROUND: Successfully completing clinical trials for rare and heterogeneous disorders, like spinal cord injuries (SCI), remains challenging, thereby reducing the ability to test and translate promising preclinical findings. We propose synthetic co...

Digital Twins for Monitoring Neuromotor Development in Preterm Infants: Conceptual Framework and Proof-of-concept Study.

Journal of medical systems
Preterm birth leads to an increased risk of long-term consequences, with over 50% of children born <30 weeks facing motor, cognitive, or behavioural impairments. Early monitoring of motor developmental trajectories, strongly associated with neurodeve...

Evaluation of an Autonomous Robotic System for Reducing Radiation Risk in a Real-World Cardiac Imaging Laboratory.

Journal of medical systems
BACKGROUND: Nuclear imaging is the cornerstone of clinical practice across many disciplines. Few innovations in imaging have addressed occupational health of radiographers exposed to radiation in their daily work. In this proof-of-concept study, we h...

A proof of concept study of F-FDG PET/CT patient-level radiomics identify refractory/relapsed diffuse large B-cell lymphoma.

Scientific reports
This study aimed to evaluate diffuse large B-cell lymphoma (DLBCL) patients who have refractory/relapsed disease and characterize the heterogeneity of DLBCL using patient-level radiomics analysis based on F-FDG PET/CT. A total of 132 patients diagnos...

Proposition of a new, minimally-invasive, software smartphone device to predict sleep apnea and its severity.

Sleep & breathing = Schlaf & Atmung
PURPOSE: obstructive sleep apnea is underdiagnosed due to limited access to polysomnography (PSG). We aimed to assess the performances of Apneal, an application recording sound and movements thanks to a smartphone's microphone, accelerometer and gyro...

Proof-of-concept evaluation at Cox's Bazar of the Safe Water Optimization Tool: water quality modelling for safe water supply in humanitarian emergencies.

BMJ global health
INTRODUCTION: Waterborne diseases are leading concerns in emergencies. Humanitarian guidelines stipulate universal water chlorination targets, but these fail to reliably protect water as postdistribution chlorine decay can leave water vulnerable to p...

Liver MRI proton density fat fraction inference from contrast enhanced CT images using deep learning: A proof-of-concept study.

PloS one
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease worldwide, affecting over 30% of the global general population. Its progressive nature and association with other chronic diseases make...

Leveraging deep learning for the detection of socially desirable tendencies in personnel selection: A proof-of-concept.

PloS one
We propose a deep learning-based method for detecting Socially Desirable Responding (SDR)-the tendency for individuals to distort questionnaire responses to present themselves in a favorable light. Our objective is to showcase that such novel methods...

Usability of machine learning algorithms based on electronic health records for the prediction of acute kidney injury and transition to acute kidney disease: A proof of concept study.

PloS one
BACKGROUND: Acute kidney injury (AKI) and acute kidney disease (AKD) are frequent complications of hospitalization, resulting in reduced outcomes and increased cost burden. However, these conditions are only sometimes recognized and promptly treated....