AIMC Topic: Rats
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Development and validation of a LC-MS/MS assay for quantification of cisplatin in rat plasma and urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Nov 23, 2016
Till date, no analytical method published to detect Cisplatin has been validated according to the U.S. Food and Drug Administration (FDA) guidance using liquid chromatography mass spectrometry (LC-MS/MS). We report, a validated LC-MS/MS method for qu...
Integration of metabolomics, lipidomics and clinical data using a machine learning method.
BMC bioinformatics
Nov 22, 2016
BACKGROUND: The recent pandemic of obesity and the metabolic syndrome (MetS) has led to the realisation that new drug targets are needed to either reduce obesity or the subsequent pathophysiological consequences associated with excess weight gain. Ce...
Apoptosis of rat hepatic stellate cells induced by diallyl trisulfide and proteomics profiling in vitro.
Canadian journal of physiology and pharmacology
Nov 18, 2016
Diallyl trisulfide (DATS), a major garlic derivative, inhibits cell proliferation and triggers apoptosis in a variety of cancer cell lines. However, the effects of DATS on hepatic stellate cells (HSCs) remain unknown. The aim of this study was to ana...
Fatty acid composition and mechanisms of the protective effects of myrtle berry seed aqueous extract in alcohol-induced peptic ulcer in rat.
Canadian journal of physiology and pharmacology
Nov 10, 2016
This study aimed to investigate the antiulcer and antioxidant activities of myrtle berry seed aqueous extract (MBSAE) in a peptic ulcer model induced by ethanol in male Wistar rats. MBSAE is rich in total polyphenols, total flavonoids, and unsaturate...
The protective effects of bone morphogenetic protein-7 against epithelial injury and matrix metalloproteases upregulation induced by silica in vitro.
Human & experimental toxicology
Oct 20, 2016
OBJECTIVE: We investigate the effects of bone morphogenetic protein-7 (BMP-7) on models with silica-induced and macrophage-mediated fibrosis and its possible mechanisms in vitro.
Dysfunction of endothelial progenitor cells in hyperlipidemic rats involves the increase of NADPH oxidase derived reactive oxygen species production.
Canadian journal of physiology and pharmacology
Oct 20, 2016
NADPH oxidase (NOX) is a major source of reactive oxygen species (ROS) in the body and it plays a key role in mediation of oxidative injury in the cardiovascular system. The purposes of this study are to evaluate the status of NOX in endothelial prog...
Brief isoflurane anaesthesia affects differential gene expression, gene ontology and gene networks in rat brain.
Behavioural brain research
Sep 19, 2016
Much is still unknown about the mechanisms of effects of even brief anaesthesia on the brain and previous studies have simply compared differential expression profiles with and without anaesthesia. We hypothesised that network analysis, in addition t...
Maze learning by a hybrid brain-computer system.
Scientific reports
Sep 13, 2016
The combination of biological and artificial intelligence is particularly driven by two major strands of research: one involves the control of mechanical, usually prosthetic, devices by conscious biological subjects, whereas the other involves the co...
Investigation of rat exploratory behavior via evolving artificial neural networks.
Journal of neuroscience methods
Jun 17, 2016
BACKGROUND: Neuroevolution comprises the use of evolutionary computation to define the architecture and/or to train artificial neural networks (ANNs). This strategy has been employed to investigate the behavior of rats in the elevated plus-maze, whic...
Effect of goat milk on hepatotoxicity induced by antitubercular drugs in rats.
Journal of food and drug analysis
Jun 2, 2016
Aim of the present study was to assess the hepatoprotective activity of goat milk on antitubercular drug-induced hepatotoxicity in rats. Hepatotoxicity was induced in rats using a combination of isoniazid, rifampicin, and pyrazinamide given orally as...
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