AIMC Topic: Sepsis

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AI Enhanced explainable early prediction of blood culture positivity in neutropenic patients using clinical and hematologic parameters.

Computers in biology and medicine
Leukemia patients who receive chemotherapy experience a decline in neutrophils and an increased risk of infections. Neutropenic sepsis is a life-threatening condition and a major cause of cancer-related mortality. Patients with neutropenic sepsis are...

Advancing sepsis diagnosis and immunotherapy machine learning-driven identification of stable molecular biomarkers and therapeutic targets.

Scientific reports
Sepsis represents a significant global health challenge, necessitating early detection and effective treatment for improved outcomes. While traditional inflammatory markers facilitate the diagnosis of sepsis, the aspect of immune suppression remains ...

Comprehensive integration of diagnostic biomarker analysis and immune cell infiltration features in sepsis via machine learning and bioinformatics techniques.

Frontiers in immunology
INTRODUCTION: Sepsis, a critical medical condition resulting from an irregular immune response to infection, leads to life-threatening organ dysfunction. Despite medical advancements, the critical need for research into dependable diagnostic markers ...

An AI-Based Clinical Decision Support System for Antibiotic Therapy in Sepsis (KINBIOTICS): Use Case Analysis.

JMIR human factors
BACKGROUND: Antimicrobial resistances pose significant challenges in health care systems. Clinical decision support systems (CDSSs) represent a potential strategy for promoting a more targeted and guideline-based use of antibiotics. The integration o...

Interpretable machine learning model for early morbidity risk prediction in patients with sepsis-induced coagulopathy: a multi-center study.

Frontiers in immunology
BACKGROUND: Sepsis-induced coagulopathy (SIC) is a complex condition characterized by systemic inflammation and coagulopathy. This study aimed to develop and validate a machine learning (ML) model to predict SIC risk in patients with sepsis.

Complete Blood Count and Monocyte Distribution Width-Based Machine Learning Algorithms for Sepsis Detection: Multicentric Development and External Validation Study.

Journal of medical Internet research
BACKGROUND: Sepsis is an organ dysfunction caused by a dysregulated host response to infection. Early detection is fundamental to improving the patient outcome. Laboratory medicine can play a crucial role by providing biomarkers whose alteration can ...

Leveraging diverse cell-death patterns in diagnosis of sepsis by integrating bioinformatics and machine learning.

PeerJ
BACKGROUND: Sepsis is a life-threatening disease causing millions of deaths every year. It has been reported that programmed cell death (PCD) plays a critical role in the development and progression of sepsis, which has the potential to be a diagnosi...

Impact of Sepsis Onset Timing on All-Cause Mortality in Acute Pancreatitis: A Multicenter Retrospective Cohort Study.

Journal of intensive care medicine
BackgroundSepsis complicates acute pancreatitis (AP), increasing mortality risk. Few studies have examined how sepsis and its onset timing affect mortality in AP. This study evaluates the association between sepsis occurrence and all-cause mortality ...

Rapid and Differential Diagnosis of Sepsis Stages Using an Advanced 3D Plasmonic Bimetallic Alloy Nanoarchitecture-Based SERS Biosensor Combined with Machine Learning for Multiple Analyte Identification.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Rapid and accurate differential diagnosis of infections, sepsis, and septic shock is essential for preventing unnecessary antibiotic overuse and improving the chance of patient survival. To address this, a 3D gold nanogranule decorated gold-silver al...