AIMC Topic: Signal Transduction
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Study on miR-384-5p activates TGF-β signaling pathway to promote neuronal damage in abutment nucleus of rats based on deep learning.
Artificial intelligence in medicine
Oct 10, 2019
BACKGROUND: Any ailment in our organs can be visualized by using different modality signals and images. Hospitals are encountering a massive influx of large multimodality patient data to be analysed accurately and with context understanding. The deep...
Analysis of defective pathways and drug repositioning in Multiple Sclerosis via machine learning approaches.
Computers in biology and medicine
Oct 9, 2019
BACKGROUND: Although some studies show that there could be a genetic predisposition to develop Multiple Sclerosis (MS), attempts to find genetic signatures related to MS diagnosis and development are extremely rare.
Designing combination therapies with modeling chaperoned machine learning.
PLoS computational biology
Sep 9, 2019
Chemotherapy resistance is a major challenge to the effective treatment of cancer. Thus, a systematic pipeline for the efficient identification of effective combination treatments could bring huge biomedical benefit. In order to facilitate rational d...
Machine Learning to Understand the Immune-Inflammatory Pathways in Fibromyalgia.
International journal of molecular sciences
Aug 29, 2019
Fibromyalgia (FM) is a chronic syndrome characterized by widespread musculoskeletal pain, and physical and emotional symptoms. Although its pathophysiology is largely unknown, immune-inflammatory pathways may be involved. We examined serum interleuki...
Artificial Intelligence Approach To Investigate the Longevity Drug.
The journal of physical chemistry letters
Aug 14, 2019
Longevity is a very important and interesting topic, and has been demonstrated to be related to longevity. We combined network pharmacology, machine learning, deep learning, and molecular dynamics (MD) simulation to investigate potent lead drugs. Re...
Inhibitory Concentration 50
Binding Sites
Thermodynamics
Receptor, IGF Type 1
Antigens, CD
Ligands
Receptor, Insulin
Drug Discovery
Protein Interaction Maps
Protein Binding
Klotho Proteins
Glucuronidase
Signal Transduction
Medicine, Chinese Traditional
Algorithms
Databases, Factual
Molecular Docking Simulation
Artificial Intelligence
Exploration of potential key pathways and genes in multiple ocular cancers through bioinformatics analysis.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Jul 15, 2019
PURPOSE: Primary cancers of the eye are common in ocular diseases. The objective of this study was to explore the underlying mechanisms and the potential target genes in multiple ocular cancers by bioinformatics approach.
Exploring the druggable space around the Fanconi anemia pathway using machine learning and mechanistic models.
BMC bioinformatics
Jul 2, 2019
BACKGROUND: In spite of the abundance of genomic data, predictive models that describe phenotypes as a function of gene expression or mutations are difficult to obtain because they are affected by the curse of dimensionality, given the disbalance bet...
A neural network model predicts community-level signaling states in a diverse microbial community.
PLoS computational biology
Jun 24, 2019
Signal crosstalk within biological communication networks is common, and such crosstalk can have unexpected consequences for decision making in heterogeneous communities of cells. Here we examined crosstalk within a bacterial community composed of fi...
Nervous-Like Circuits in the Ribosome Facts, Hypotheses and Perspectives.
International journal of molecular sciences
Jun 14, 2019
In the past few decades, studies on translation have converged towards the metaphor of a "ribosome nanomachine"; they also revealed intriguing ribosome properties challenging this view. Many studies have shown that to perform an accurate protein synt...
Assessment of risk based on variant pathways and establishment of an artificial neural network model of thyroid cancer.
BMC medical genetics
May 28, 2019
BACKGROUND: This study aimed to establish an artificial neural network (ANN) model based on variant pathways to predict the risk of thyroid cancer.
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