AIMC Topic: Signal Transduction
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Single-cell approaches to cell competition: High-throughput imaging, machine learning and simulations.
Seminars in cancer biology
May 18, 2019
Cell competition is a quality control mechanism in tissues that results in the elimination of less fit cells. Over the past decade, the phenomenon of cell competition has been identified in many physiological and pathological contexts, driven either ...
Systems Pharmacological Approach to Investigate the Mechanism of for Application to Alzheimer's Disease.
Molecules (Basel, Switzerland)
Apr 17, 2019
(OC)-a traditional Chinese medicine (TCM)-has been reported to have large numbers of flavonoids, alkaloids, and triterpenoids. The previous studies on OC for treating Alzheimer's disease (AD) only focused on single targets and its mechanisms, while ...
Analysis of differentially expressed genes in rheumatoid arthritis and osteoarthritis by integrated microarray analysis.
Journal of cellular biochemistry
Mar 4, 2019
BACKGROUND: Rheumatoid arthritis (RA) and osteoarthritis (OA) were two major types of joint diseases. This study aimed to explore the mechanism underlying OA and RA and analyze their difference by integrated analysis of multiple gene expression data ...
Gene Expression Regulation
Chemokines
Oligonucleotide Array Sequence Analysis
Arthritis, Rheumatoid
Ubiquitin-Protein Ligases
Humans
Oxidative Phosphorylation
Signal Transduction
Gene Ontology
Gene Expression Profiling
Inhibitor of Apoptosis Proteins
Synovial Membrane
Protein Interaction Maps
Osteoarthritis
Gene Regulatory Networks
Grape Seed Proanthocyanidin Extract Inhibits Human Esophageal Squamous Cancerous Cell Line ECA109 via the NF-B Signaling Pathway.
Mediators of inflammation
Dec 17, 2018
Esophageal squamous cell carcinoma is the most common type of squamous cell carcinoma. Grape seed proanthocyanidin extract (GSPE) is considered to exhibit anticancer activity against several different types of cancer. We aimed to determine whether GS...
Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-B/p65 Signaling in Chronic Radiculitis Rats.
Pain research & management
Dec 13, 2018
BACKGROUND: Oxygen/ozone therapy is a minimally invasive technique for the treatment of radiculitis from lumbar disc herniation. This study aimed at investigating whether intrathecal administration of low-concentration oxygen/ozone could attenuate ch...
Found In Translation: a machine learning model for mouse-to-human inference.
Nature methods
Nov 26, 2018
Cross-species differences form barriers to translational research that ultimately hinder the success of clinical trials, yet knowledge of species differences has yet to be systematically incorporated in the interpretation of animal models. Here we pr...
Gene ontology enrichment analysis of congenital diaphragmatic hernia-associated genes.
Pediatric research
Sep 25, 2018
Congenital diaphragmatic hernia (CDH) is a commonly occurring major congenital anomaly with a profound impact on neonatal mortality. The etiology of CDH is poorly understood and is complicated by multiple clinical presentations, reflecting the locati...
RNA-seq analysis reveals different gene ontologies and pathways in rheumatoid arthritis and Kashin-Beck disease.
International journal of rheumatic diseases
Sep 5, 2018
AIMS: To understand the pathogenesis of cartilage damage in Kashin-Beck disease (KBD) and rheumatoid arthritis (RA) which similar clinical symptoms.
Identification of novel immune-relevant drug target genes for Alzheimer's Disease by combining ontology inference with network analysis.
CNS neuroscience & therapeutics
Aug 14, 2018
AIMS: Alzheimer's disease (AD) is one of the leading causes of death in elderly people. Its pathogenesis is greatly associated with the abnormality of immune system. However, only a few immune-relevant AD drug target genes have been discovered up to ...
Machine learning approaches infer vitamin D signaling: Critical impact of vitamin D receptor binding within topologically associated domains.
The Journal of steroid biochemistry and molecular biology
Jul 22, 2018
The vitamin D-modulated transcriptome of highly responsive human cells, such as THP-1 monocytes, comprises more than 500 genes, half of which are primary targets. Recently, we proposed a chromatin model of vitamin D signaling demonstrating that nearl...
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