The accurate identification of DNA sequence variants is an important, but challenging task in genomics. It is particularly difficult for single molecule sequencing, which has a per-nucleotide error rate of ~5-15%. Meeting this demand, we developed Cl...
BACKGROUND: A large fraction of human and mouse autosomal genes are subject to random monoallelic expression (MAE), an epigenetic mechanism characterized by allele-specific gene expression that varies between clonal cell lineages. MAE is highly cell-...
OBJECTIVE: Obstructive sleep-disordered breathing (SDB) events, unlike central events, are associated with increased respiratory effort. Esophageal pressure (P ) monitoring is the gold standard for measuring respiratory effort, but it is typically po...
Investigating crimes against children, specifically sexual solicitations, are complicated because not all offenders are contact-driven, meaning they want to meet the minor for sex in the physical world; instead, some offenders are fantasy-driven, in ...
International journal of molecular sciences
Feb 23, 2019
The interactions between ncRNAs and proteins are critical for regulating various cellular processes in organisms, such as gene expression regulations. However, due to limitations, including financial and material consumptions in recent experimental m...
Automated quantitative image analysis is essential for all fields of life science research. Although several software programs and algorithms have been developed for bioimage processing, an advanced knowledge of image processing techniques and high-p...
Interdisciplinary sciences, computational life sciences
Feb 21, 2019
Many scientific applications entail solving the subgraph isomorphism problem, i.e., given an input pattern graph, find all the subgraphs of a (usually much larger) target graph that are structurally equivalent to that input. Because subgraph isomorph...
Fault diagnostic software is required to respond to faults as early as possible in time-critical applications. However, the existing methods based on early diagnosis are not adequate. First, there is no common standard to quantify the response time o...
Microarray technique is a prevalent method for the classification and prediction of colorectal cancer (CRC). Nevertheless, microarray data suffers from the curse of dimensionality when selecting feature genes of the disease based on imbalance samples...
Computational intelligence and neuroscience
Feb 20, 2019
Software effort estimation plays a critical role in project management. Erroneous results may lead to overestimating or underestimating effort, which can have catastrophic consequences on project resources. Machine-learning techniques are increasingl...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.