AIMC Topic: Squamous Cell Carcinoma of Head and Neck
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Identification of DSC2 as a Key Biomarker for Induction Chemotherapy Sensitivity in Locally Advanced Laryngeal and Hypopharyngeal Squamous Cell Carcinoma.
Journal of chemical information and modeling
Jun 9, 2025
Patients with locally advanced laryngeal and hypopharyngeal squamous cell carcinoma (LA-LHSCC) urgently need precise treatment strategies to improve the prognosis due to severe laryngeal functional impairment following traditional surgery and chemora...
Artificial Intelligence for Head and Neck Squamous Cell Carcinoma: From Diagnosis to Treatment.
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
Jun 9, 2025
Head and neck squamous cell carcinoma (HNSCC) remains a globally prevalent malignancy with high morbidity and mortality. Despite therapeutic advances, patient outcomes are hindered by tumor heterogeneity, treatment-related toxicity, and the limitatio...
Integrative bioinformatics and machine learning identify key crosstalk genes and immune interactions in head and neck cancer and Hodgkin lymphoma.
Scientific reports
May 6, 2025
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive malignancy with complex molecular underpinnings. Hodgkin lymphoma (HL), another distinct cancer type, shares several biological characteristics with HNSCC, particularly regarding im...
Use of ChatGPT for patient education involving HPV-associated oropharyngeal cancer.
American journal of otolaryngology
Apr 21, 2025
OBJECTIVE: This study aims to investigate the ability of ChatGPT to generate reliably accurate responses to patient-based queries specifically regarding oropharyngeal squamous cell carcinoma (OPSCC) of the head and neck.
Histological tumor necrosis predicts decreased survival after neoadjuvant chemotherapy in head and neck squamous cell carcinoma.
Oral oncology
Apr 16, 2025
OBJECTIVE: Despite growing interest in neoadjuvant therapies, there are no methods to predict radio- (RT) or chemoradiotherapy (CRT) response in head and neck squamous cell carcinoma (HNSCC). The aim of this research was to study the effect of neoadj...
Pathogenomic fingerprinting to identify associations between tumor morphology and epigenetic states.
European journal of cancer (Oxford, England : 1990)
Apr 14, 2025
INTRODUCTION: Measuring the chromatin state of a tumor provides a powerful map of its epigenetic commitments; however, as these are generally bulk measurements, it has not yet been possible to connect changes in chromatin accessibility to the patholo...
Artificial intelligence-based virtual staining platform for identifying tumor-associated macrophages from hematoxylin and eosin-stained images.
European journal of cancer (Oxford, England : 1990)
Mar 26, 2025
BACKGROUND: Virtual staining is an artificial intelligence-based approach that transforms pathology images between stain types, such as hematoxylin and eosin (H&E) to immunohistochemistry (IHC), providing a tissue-preserving and efficient alternative...
Deep learning informed multimodal fusion of radiology and pathology to predict outcomes in HPV-associated oropharyngeal squamous cell carcinoma.
EBioMedicine
Mar 22, 2025
BACKGROUND: We aim to predict outcomes of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC), a subtype of head and neck cancer characterized with improved clinical outcome and better response to therapy. Pathology an...
Optimizing fractionation schedules for de-escalation radiotherapy in head and neck cancers using deep reinforcement learning.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Mar 14, 2025
PURPOSE: Patients with locally-advanced head and neck squamous cell carcinomas (HNSCCs), particularly those related to human papillomavirus (HPV), often achieve good locoregional control (LRC), yet they suffer significant toxicities from standard che...
Analysis of AI foundation model features decodes the histopathologic landscape of HPV-positive head and neck squamous cell carcinomas.
Oral oncology
Mar 4, 2025
OBJECTIVES: Human papillomavirus (HPV) influences the pathobiology of Head and Neck Squamous Cell Carcinomas (HSNCCs). While deep learning shows promise in detecting HPV from hematoxylin and eosin (H&E) stained slides, the histologic features utilize...
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