AIMC Topic: Tandem Mass Spectrometry
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Determination of Oleandrin in Blood and Liver Samples by LC-MS/MS.
Fa yi xue za zhi
Dec 25, 2018
OBJECTIVES: To develop a liquid chromatography-tandem mass spectrometry （LC-MS/MS） analytical method for the determination of oleandrin in blood and liver tissues, which could be applied to the cases of death caused by oleander poisoning.
Determination of 17 potential endocrine-disrupting chemicals in human saliva by dispersive liquid-liquid microextraction and liquid chromatography-tandem mass spectrometry.
Talanta
Dec 23, 2018
Endocrine-disrupting chemicals are a group of emerging contaminants that alters the function of the endocrine system, causing possible adverse health effects. In this study, a dispersive liquid-liquid microextraction method coupled with liquid chroma...
Derivatization enhances analysis of estrogens and their bioactive metabolites in human plasma by liquid chromatography tandem mass spectrometry.
Analytica chimica acta
Dec 21, 2018
Estrogens regulate many diverse biological processes in health and disease. They circulate at a wide range of concentrations in females generating several active metabolites (hydroxy and methoxyestrogens). The metabolites are assumed to be present in...
Magnetic γ-cyclodextrin polymer with compatible cavity promote the magnetic solid-phase extraction of microcystins in water samples.
Analytica chimica acta
Dec 21, 2018
Microcystins (MCs), which are produced by eruptive cyanobacteria, seriously threaten the health of humans for their poisonousness. Herein, a facile strategy was introduced to synthesize the magnetic γ-cyclodextrin polymer (FeO@PDA@γ-CDP) composite an...
Retrospective Data Analysis of the Influence of Age and Sex on TPMT Activity and Its Phenotype-Genotype Correlation.
The journal of applied laboratory medicine
Dec 20, 2018
BACKGROUND: Therapeutic efficacy and toxicity of thiopurine drugs (used as anticancer and immunosuppressant agents) are affected by thiopurine S-methyltransferase (TPMT) enzyme activity. genotype and/or phenotype is used to predict the risk for adve...
Effect of Wuziyanzong pill on metabolism of dapoxetine in vivo and in vitro.
Journal of pharmaceutical and biomedical analysis
Dec 15, 2018
In vitro incubation of rat liver microsomes with 30 μL of 100 μmol·L dapoxetine and 30 μL of 10, 100, 250, 500, 1000, 2500, or 5000 μg·mL Wuziyanzong pill was performed at 37 °C for 60 min. Dapoxetine concentration was analyzed by high performance li...
UHPLC-MS/MS method for simultaneous determination of carbamazepine and its seven major metabolites in serum of epileptic patients.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Dec 14, 2018
Carbamazepine (CBZ) was considered as the drug of choice in the treatment for various forms of epilepsy, yet the non-negligible adverse effects of CBZ suspend as the major concern for rational and efficient clinical medication. This study developed a...
A 6 Second Analytical Method for Quantitation of Tacrolimus in Whole Blood by Use of Laser Diode Thermal Desorption Tandem Mass Spectrometry.
The journal of applied laboratory medicine
Dec 7, 2018
BACKGROUND: Therapeutic drug monitoring of immunosuppressive drugs is imperative for organ transplant recipients. High-performance LC-MS/MS is considered gold standard; however, immunoassays provide rapid turnaround time. New technology was developed...
Effect of inter-individual variability in human liver cytochrome P450 isozymes on cyclophosphamide-induced micronucleus formation.
Mutation research. Genetic toxicology and environmental mutagenesis
Dec 5, 2018
We investigated the relationship between metabolic activities of cytochrome P450 (CYP) isozymes present in microsomal fractions derived from the livers of 78 donors and micronucleus induction by cyclophosphamide (CPA). Consequently, a wide inter-indi...
Ultra-high-performance liquid chromatography-mass spectrometry method for neutrophil gelatinase-associated lipocalin as a predictive biomarker in acute kidney injury.
Talanta
Dec 1, 2018
Neutrophil gelatinase associated lipocalin (NGAL) is a protein that was found to be overexpressed in acute kidney injury (AKI). The rise in NGAL concentration, both in urine or plasma, appears earlier than for other classical renal function markers s...
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