AIMC Topic: Tissue Engineering
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Applications of Computer Modeling and Simulation in Cartilage Tissue Engineering.
Tissue engineering and regenerative medicine
Oct 5, 2019
BACKGROUND: Advances in cartilage tissue engineering have demonstrated noteworthy potential for developing cartilage for implantation onto sites impacted by joint degeneration and injury. To supplement resource-intensive in vivo and in vitro studies ...
Improving the Rate of Translation of Tissue Engineering Products.
Advanced healthcare materials
Aug 6, 2019
Over 100 000 research articles and 9000 patents have been published on tissue engineering (TE) in the past 20 years. Yet, very few TE products have made their way to the market during the same period. Experts have proposed a variety of strategies to ...
A Remotely Controlled Transformable Soft Robot Based on Engineered Cardiac Tissue Construct.
Small (Weinheim an der Bergstrasse, Germany)
Mar 25, 2019
Many living organisms undergo conspicuous or abrupt changes in body structure, which is often accompanied by a behavioral change. Inspired by the natural metamorphosis, robotic systems can be designed as reconfigurable to be multifunctional. Here, a ...
Acquisition and reconstruction of 4D surfaces of axolotl embryos with the flipping stage robotic microscope.
Bio Systems
Oct 25, 2018
We have designed and constructed a Flipping Stage for a light microscope that can view the whole exterior surface of a 2 mm diameter developing axolotl salamander embryo. It works by rapidly inverting the bottom-heavy embryo, imaging it as it rights ...
Learning-Based Cell Injection Control for Precise Drop-on-Demand Cell Printing.
Annals of biomedical engineering
Jun 5, 2018
Drop-on-demand (DOD) printing is widely used in bioprinting for tissue engineering because of little damage to cell viability and cost-effectiveness. However, satellite droplets may be generated during printing, deviating cells from the desired posit...
Assessing functional connectivity across 3D tissue engineered axonal tracts using calcium fluorescence imaging.
Journal of neural engineering
Jun 1, 2018
OBJECTIVE: Micro-tissue engineered neural networks (micro-TENNs) are anatomically-inspired constructs designed to structurally and functionally emulate white matter pathways in the brain. These 3D neural networks feature long axonal tracts spanning d...
Substrate stiffness affects neural network activity in an extracellular matrix proteins dependent manner.
Colloids and surfaces. B, Biointerfaces
Mar 27, 2018
Neuronal growth, differentiation, extension, branching and neural network activity are strongly influenced by the mechanical property of extracellular matrix (ECM). However, the mechanism by which substrate stiffness regulates a neural network activi...
Kinase inhibitor screening using artificial neural networks and engineered cardiac biowires.
Scientific reports
Sep 18, 2017
Kinase inhibitors are often used as cancer targeting agents for their ability to prevent the activation of cell growth and proliferation signals. Cardiotoxic effects have been identified for some marketed kinase inhibitors that were not detected duri...
Optimized Repopulation of Tendon Hydrogel: Synergistic Effects of Growth Factor Combinations and Adipose-Derived Stem Cells.
Hand (New York, N.Y.)
Mar 15, 2016
Tendon-derived extracellular matrix (ECM) hydrogel has been shown to augment tendon healing in vivo. We hypothesized that reseeding of the gel with adipose-derived stem cells (ASCs) could further assist repopulation of the gel and that combinations ...
Coefficient of Friction Patterns Can Identify Damage in Native and Engineered Cartilage Subjected to Frictional-Shear Stress.
Annals of biomedical engineering
Feb 18, 2015
The mechanical loading environment encountered by articular cartilage in situ makes frictional-shear testing an invaluable technique for assessing engineered cartilage. Despite the important information that is gained from this testing, it remains un...
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