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Tissue Engineering

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Substrate stiffness affects neural network activity in an extracellular matrix proteins dependent manner.

Colloids and surfaces. B, Biointerfaces
Neuronal growth, differentiation, extension, branching and neural network activity are strongly influenced by the mechanical property of extracellular matrix (ECM). However, the mechanism by which substrate stiffness regulates a neural network activi...

Kinase inhibitor screening using artificial neural networks and engineered cardiac biowires.

Scientific reports
Kinase inhibitors are often used as cancer targeting agents for their ability to prevent the activation of cell growth and proliferation signals. Cardiotoxic effects have been identified for some marketed kinase inhibitors that were not detected duri...

Optimized Repopulation of Tendon Hydrogel: Synergistic Effects of Growth Factor Combinations and Adipose-Derived Stem Cells.

Hand (New York, N.Y.)
Tendon-derived extracellular matrix (ECM) hydrogel has been shown to augment tendon healing in vivo. We hypothesized that reseeding of the gel with adipose-derived stem cells (ASCs) could further assist repopulation of the gel and that combinations ...

Coefficient of Friction Patterns Can Identify Damage in Native and Engineered Cartilage Subjected to Frictional-Shear Stress.

Annals of biomedical engineering
The mechanical loading environment encountered by articular cartilage in situ makes frictional-shear testing an invaluable technique for assessing engineered cartilage. Despite the important information that is gained from this testing, it remains un...

What insights can spatiotemporal esophageal atlases and deep learning bring to engineering the esophageal mucosa?

Developmental cell
In this issue of Developmental Cell, Yang et al. present an integrated experimental and computational platform that maps the spatiotemporal development of the human esophagus and predicts key signaling pathways governing epithelial differentiation. T...

Recent advances in artificial intelligent strategies for tissue engineering and regenerative medicine.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
BACKGROUND: Tissue engineering and regenerative medicine (TERM) aim to repair or replace damaged or lost tissues or organs due to accidents, diseases, or aging, by applying different sciences. For this purpose, an essential part of TERM is the design...

Biofabrication of Living Actuators.

Annual review of biomedical engineering
The impact of tissue engineering has extended beyond a traditional focus in medicine to the rapidly growing realm of biohybrid robotics. Leveraging living actuators as functional components in machines has been a central focus of this field, generati...

Design optimization of geometrically confined cardiac organoids enabled by machine learning techniques.

Cell reports methods
Stem cell organoids are powerful models for studying organ development, disease modeling, drug screening, and regenerative medicine applications. The convergence of organoid technology, tissue engineering, and artificial intelligence (AI) could poten...

3D-Bioprinting and AI-empowered Anatomical Structure Designing: A Review.

Current medical imaging
BACKGROUND: The recent advancements and detailed studies in the field of 3D bioprinting have made it a promising avenue in the field of organ shortage, where many patients die awaiting transplantation. The main challenges bioprinting faces are precis...

Photonic artificial muscles: from micro robots to tissue engineering.

Faraday discussions
Light responsive shape-changing polymers are able to mimic the function of biological muscles accomplishing mechanical work in response to selected stimuli. A variety of manufacturing techniques and chemical processes can be employed to shape these m...