AIMC Topic: Transfection
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Machine learning-assisted design of immunomodulatory lipid nanoparticles for delivery of mRNA to repolarize hyperactivated microglia.
Drug delivery
Mar 3, 2025
Regulating inflammatory microglia presents a promising strategy for treating neurodegenerative and autoimmune disorders, yet effective therapeutic agents delivery to these cells remains a challenge. This study investigates modified lipid nanoparticle...
Optimizing lipid nanoparticles for fetal gene delivery in vitro, ex vivo, and aided with machine learning.
Journal of controlled release : official journal of the Controlled Release Society
Oct 28, 2024
There is a clinical need to develop lipid nanoparticles (LNPs) to deliver congenital therapies to the fetus during pregnancy. The aim of these therapies is to restore normal fetal development and prevent irreversible conditions after birth. As a firs...
Synergistic Polymer Blending Informs Efficient Terpolymer Design and Machine Learning Discerns Performance Trends for pDNA Delivery.
Bioconjugate chemistry
Jun 26, 2024
Cationic polymers offer an alternative to viral vectors in nucleic acid delivery. However, the development of polymer vehicles capable of high transfection efficiency and minimal toxicity has remained elusive, and continued exploration of the vast de...
Artificial Intelligence (AI)-Aided Structure Optimization for Enhanced Gene Delivery: The Effect of the Polymer Component Distribution (PCD).
ACS applied materials & interfaces
Jul 21, 2023
Gene therapy has emerged as a significant advancement in medicine in recent years. However, the development of effective gene delivery vectors, particularly polymer vectors, remains a significant challenge. Limited understanding of the internal struc...
Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation.
Cell death & disease
Dec 17, 2021
Therapies halting the progression of fibrosis are ineffective and limited. Activated myofibroblasts are emerging as important targets in the progression of fibrotic diseases. Previously, we performed a high-throughput screen on lung fibroblasts and s...
Optimizing Lipofectamine LTX Complex and G-418 Concentration for Improvement of Transfection Efficiency in Human Mesenchymal Stem Cells.
Archives of Razi Institute
Nov 30, 2021
Conventional cancer therapies, including surgery, radiotherapy, and chemotherapy, are not tumor site-specific and have cytotoxic and harmful side effects for normal cells. Mesenchymal stem cells (MSCs), due to their tumor-tropism migration property, ...
An Integrated Approach toward NanoBRET Tracers for Analysis of GPCR Ligand Engagement.
Molecules (Basel, Switzerland)
May 12, 2021
Gaining insight into the pharmacology of ligand engagement with G-protein coupled receptors (GPCRs) under biologically relevant conditions is vital to both drug discovery and basic research. NanoLuc-based bioluminescence resonance energy transfer (Na...
Development of Simplified in Vitro P-Glycoprotein Substrate Assay and in Silico Prediction Models To Evaluate Transport Potential of P-Glycoprotein.
Molecular pharmaceutics
Apr 16, 2019
For efficient drug discovery and screening, it is necessary to simplify P-glycoprotein (P-gp) substrate assays and to provide in silico models that predict the transport potential of P-gp. In this study, we developed a simplified in vitro screening m...
Machine Learning
Central Nervous System Agents
Transfection
Drug Discovery
Data Accuracy
Biological Availability
Swine
ATP Binding Cassette Transporter, Subfamily B
Computer Simulation
Cell Membrane Permeability
ATP Binding Cassette Transporter, Subfamily B, Member 1
LLC-PK1 Cells
Reproducibility of Results
Protein Transport
Drug Evaluation, Preclinical
Animals
Intestinal Absorption
Scalable Device for Automated Microbial Electroporation in a Digital Microfluidic Platform.
ACS synthetic biology
Jun 7, 2017
Electrowetting-on-dielectric (EWD) digital microfluidic laboratory-on-a-chip platforms demonstrate excellent performance in automating labor-intensive protocols. When coupled with an on-chip electroporation capability, these systems hold promise for ...
Synthesis of Water-Soluble Imidazolium Polyesters as Potential Nonviral Gene Delivery Vehicles.
Biomacromolecules
Dec 8, 2016
The inherent hydrolytic reactivity of polyesters renders them excellent candidates for a variety of biomedical applications. Incorporating ionic groups further expands their potential impact, encompassing charge-dependent function such as deoxyribonu...
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