AIMC Topic: Treatment Outcome
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Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis.
Nature communications
Jul 2, 2025
Approximately 40% of patients with rheumatoid arthritis do not respond to individual biologic therapies, while biomarkers predictive of treatment response are lacking. Here we analyse RNA-sequencing (RNA-Seq) of pre-treatment synovial tissue from the...
The construction of HMME-PDT efficacy prediction model for port-wine stain based on machine learning algorithms.
Scientific reports
Jul 2, 2025
Hematoporphyrin monomethyl ether-photodynamic therapy (HMME-PDT) is a safe and effective treatment for port-wine stain (PWS). Comprehensive methods for predicting HMME-PDT efficacy based on clinical factors are lacking. This study aims to develop and...
Preoperative prediction of major adverse outcomes after total arch replacement in acute type A aortic dissection based on machine learning ensemble.
Scientific reports
Jul 1, 2025
A machine learning model was developed and validated to predict postoperative complications in patients with acute type A aortic dissection (ATAAD) who underwent total arch replacement combined with frozen elephant trunk (TAR + FET), with the goal of...
Personalized azithromycin treatment rules for children with watery diarrhea using machine learning.
Nature communications
Jul 1, 2025
We use machine learning to identify innovative strategies to target azithromycin to the children with watery diarrhea who are most likely to benefit. Using data from a randomized trial of azithromycin for watery diarrhea (NCT03130114), we develop per...
Treatment Response Evaluation in Prostate Cancer Using PSMA PET/CT.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Jul 1, 2025
In recent years, there has been a headlong rush into the use of prostate-specific membrane antigen (PSMA)-targeted PET for the staging and restaging of men with prostate cancer (PC). To date, there have been regulatory approvals for PSMA PET for purp...
Individual muscle strengths in rehabilitation outcomes of distal radius fracture.
Journal of neuroengineering and rehabilitation
Jun 24, 2025
BACKGROUND: Distal radius fractures (DRFs) are common fracture types and elderly patients often struggle to achieve functional recovery, which could be overcome by precise rehabilitation. This study aims to develop an innovative approach for acquirin...
Sleep disturbances and PTSD: identifying baseline predictors of insomnia response in an intensive treatment programme.
European journal of psychotraumatology
Jun 23, 2025
This study examined whether baseline demographic and clinical variables could predict clinically significant reductions in insomnia symptoms among veterans receiving a 2-week Cognitive Processing Therapy (CPT)-based intensive PTSD treatment programm...
Multimodal deep learning for predicting neoadjuvant treatment outcomes in breast cancer: a systematic review.
Biology direct
Jun 23, 2025
BACKGROUND: Pathological complete response (pCR) to neoadjuvant systemic therapy (NAST) is an established prognostic marker in breast cancer (BC). Multimodal deep learning (DL), integrating diverse data sources (radiology, pathology, omics, clinical)...
Neural mechanisms underlying the improvement of gait disturbances in stroke patients through robot-assisted gait training based on QEEG and fNIRS: a randomized controlled study.
Journal of neuroengineering and rehabilitation
Jun 18, 2025
BACKGROUND: Robot-assisted gait training is more effective in improving lower limb function and walking ability in stroke patients compared to conventional rehabilitation, but the neural mechanisms remain unclear. This study aims to explore the effec...
Research on the evaluation and rehabilitation training system of upper limb motor function for poststroke patients based on artificial intelligence: a study protocol for a randomized controlled trial.
Trials
Jun 13, 2025
BACKGROUND: Stroke-induced upper limb dysfunction requires functional assessment and rehabilitation. The intelligent rehabilitation assessment and virtual reality training system for upper limb motor function in stroke can accurately and objectively ...
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