BACKGROUND: Combination immunotherapies, such as pembrolizumab plus lenvatinib (PL), are commonly used in treatment for unresectable hepatocellular carcinoma (uHCC). However, it remains challenging to predict which patients will benefit from this the...
Continuous kidney replacement therapy (CKRT) is an essential treatment for uncontrolled severe metabolic acidosis. However, CKRT can increase workload and lead to complications, thus necessitating its selective application to patients who stand to be...
Inferential statistics traditionally used in clinical trials can miss relationships between clinical phenotypes and treatment responses. We simulated a randomised clinical trial to explore how gradient boosting (XGBoost) machine learning compares wit...
INTRODUCTION: Knee osteoarthritis (KOA) is a prevalent degenerative joint disorder affecting a significant portion of the elderly population. Despite the availability of various non-surgical and pharmacological treatments, their effectiveness is ofte...
BACKGROUND: It remains unclear whether certain individuals with type 2 diabetes (T2D) derive greater cardiovascular benefit from GLP-1 receptor agonists (GLP-1RAs). Here, we integrate individual-level data from cardiovascular outcome trials (CVOTs) a...
BACKGROUND: The clinical significance and contribution of the lipid profile in atherosclerosis are well established. However, further investigation is needed in stroke patients, particularly regarding apolipoprotein B100 (ApoB100), a novel non-tradit...
BACKGROUND: Depression exhibits significant heterogeneity in antidepressant treatment response. This study aimed to develop an Electroencephalography (EEG)-based machine learning model integrating multidimensional features to predict selective seroto...
BACKGROUND: Current cancer staging methods cannot accurately predict survival outcomes and therapeutic benefits in cancer patients. Digital pathomics, a rapidly evolving field, holds significant potential to revolutionize disease evaluation.
All medications currently used to treat schizophrenia, which exert their therapeutic effects by inhibiting dopaminergic neurotransmission, have their greatest efficacy against the positive symptoms of schizophrenia but have limited impact on negative...
Archives of orthopaedic and trauma surgery
Oct 10, 2025
AIMS: The aim of this retrospective study was the evaluation of the patient-reported and radiological outcome of intravenous Iloprost therapy in the treatment of spontaneous osteonecrosis of the knee (SONK).
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