AIMC Topic: Tumor Microenvironment
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Dual-path neural network extracts tumor microenvironment information from whole slide images to predict molecular typing and prognosis of Glioma.
Computer methods and programs in biomedicine
Jan 4, 2025
BACKGROUND AND OBJECTIVE: Utilizing AI to mine tumor microenvironment information in whole slide images (WSIs) for glioma molecular subtype and prognosis prediction is significant for treatment. Existing weakly-supervised learning frameworks based on...
Machine learning based identification of an amino acid metabolism related signature for predicting prognosis and immune microenvironment in pancreatic cancer.
BMC cancer
Jan 3, 2025
BACKGROUND: Pancreatic cancer is a highly aggressive neoplasm characterized by poor diagnosis. Amino acids play a prominent role in the occurrence and progression of pancreatic cancer as essential building blocks for protein synthesis and key regulat...
Multiomics integration and machine learning reveal prognostic programmed cell death signatures in gastric cancer.
Scientific reports
Dec 28, 2024
Gastric cancer (GC) is characterized by notable heterogeneity and the impact of molecular subtypes on treatment and prognosis. The role of programmed cell death (PCD) in cellular processes is critical, yet its specific function in GC is underexplored...
Integration of Graph Neural Networks and multi-omics analysis identify the predictive factor and key gene for immunotherapy response and prognosis of bladder cancer.
Journal of translational medicine
Dec 23, 2024
OBJECTIVE: The evaluation of the efficacy of immunotherapy is of great value for the clinical treatment of bladder cancer. Graph Neural Networks (GNNs), pathway analysis and multi-omics analysis have shown great potential in the field of cancer diagn...
Computational Biology
Immunotherapy
Multiomics
Gene Expression Regulation, Neoplastic
Reproducibility of Results
Tumor Microenvironment
Cell Line, Tumor
Single-Cell Analysis
Apoptosis
Proteasome Endopeptidase Complex
Cell Proliferation
Treatment Outcome
Urinary Bladder Neoplasms
Cell Movement
Humans
Neural Networks, Computer
Prognosis
From multi-omics to predictive biomarker: AI in tumor microenvironment.
Frontiers in immunology
Dec 23, 2024
In recent years, tumors have emerged as a major global health threat. An increasing number of studies indicate that the production, development, metastasis, and elimination of tumor cells are closely related to the tumor microenvironment (TME). Advan...
Spatially-resolved analyses of muscle invasive bladder cancer microenvironment unveil a distinct fibroblast cluster associated with prognosis.
Frontiers in immunology
Dec 20, 2024
BACKGROUND: Muscle-invasive bladder cancer (MIBC) is a prevalent cancer characterized by molecular and clinical heterogeneity. Assessing the spatial heterogeneity of the MIBC microenvironment is crucial to understand its clinical significance.
Pinpointing the integration of artificial intelligence in liver cancer immune microenvironment.
Frontiers in immunology
Dec 20, 2024
Liver cancer remains one of the most formidable challenges in modern medicine, characterized by its high incidence and mortality rate. Emerging evidence underscores the critical roles of the immune microenvironment in tumor initiation, development, p...
Exploring tumor microenvironment interactions and apoptosis pathways in NSCLC through spatial transcriptomics and machine learning.
Cellular oncology (Dordrecht, Netherlands)
Dec 19, 2024
BACKGROUND: The most common type of lung cancer is non-small cell lung cancer (NSCLC), accounting for 85% of all cases. Programmed cell death (PCD), an important regulatory mechanism for cell survival and homeostasis, has become increasingly prominen...
Machine learning-based selection of immune cell markers in osteosarcoma: prognostic determination and validation of CLK1 in disease progression.
Frontiers in immunology
Dec 17, 2024
INTRODUCTION: Osteosarcoma (OS) is a malignancy of the bone that mainly afflicts younger individuals. Despite existing treatment approaches, patients with metastatic or recurrent disease generally face poor prognoses. A greater understanding of the t...
Disease Progression
Cell Line, Tumor
Gene Expression Regulation, Neoplastic
Cell Proliferation
Lymphocytes, Tumor-Infiltrating
Osteosarcoma
Bone Neoplasms
Protein-Tyrosine Kinases
Female
Tumor Microenvironment
Humans
Biomarkers, Tumor
DNA Copy Number Variations
Machine Learning
Protein Serine-Threonine Kinases
Male
Prognosis
Targeting liver cancer stem cells: the prognostic significance of MRPL17 in immunotherapy response.
Frontiers in immunology
Dec 17, 2024
BACKGROUND: Liver hepatocellular carcinoma (LIHC) ranks as the foremost cause of cancer-related deaths worldwide, and its early detection poses considerable challenges. Current prognostic indicators, including alpha-fetoprotein, have notable limitati...
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