Investigative ophthalmology & visual science
Oct 3, 2023
PURPOSE: This study aimed to establish an image-based classification that can reveal the clinical characteristics of patients with dry eye using unsupervised learning methods.
The widespread adoption of high-throughput omics technologies has exponentially increased the amount of protein sequence data involved in many salient disease pathways and their respective therapeutics and diagnostics. Despite the availability of lar...
The latent features extracted from the multiple sequence alignments (MSAs) of homologous protein families are useful for identifying residue-residue contacts, predicting mutation effects, shaping protein evolution, etc. Over the past three decades, a...
Cerebral cortex (New York, N.Y. : 1991)
Jun 20, 2023
Successful neuromodulation approaches to alter episodic memory require closed-loop stimulation predicated on the effective classification of brain states. The practical implementation of such strategies requires prior decisions regarding electrode im...
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
Jun 1, 2023
The stability of biopharmaceutical therapeutics over the storage period/shelf life has been a challenging concern for manufacturers. A noble strategy for mapping best and suitable storage conditions for recombinant human serum albumin (rHSA) in labor...
Single-cell RNA-seq analysis has become a powerful tool to analyse the transcriptomes of individual cells. In turn, it has fostered the possibility of screening thousands of single cells in parallel. Thus, contrary to the traditional bulk measurement...
Studies in health technology and informatics
May 18, 2023
This paper aimed to detect the latent clusters of patients with opioid use disorder and to identify the risk factors affecting drug misuse using unsupervised machine learning. The cluster with the highest proportion of successful treatment outcomes w...
Synaptic plasticity, or the ability of a brain to change one or more of its functions or structures at the synaptic level, has generated and is still generating a lot of interest from the scientific community especially from neuroscientists. These in...
Allostery in proteins involves, broadly speaking, ligand-induced conformational transitions that modulate function at active sites distal to where the ligand binds. In contrast, the concept of cooperativity (in the sense used in phase transition theo...