Journal of computational biology : a journal of computational molecular cell biology
Jan 3, 2020
The increasing availability of complex data in biology and medicine has promoted the use of machine learning in classification tasks to address important problems in translational and fundamental science. Two important obstacles, however, may limit t...
Journal of computational biology : a journal of computational molecular cell biology
Aug 30, 2019
The folding of a protein structure is a process governed by both local and nonlocal interactions. While incorporating local dependencies into a machine learning algorithm for protein structure prediction is simple and has been exploited for some time...
Journal of computational biology : a journal of computational molecular cell biology
Oct 31, 2018
The gene ontology (GO) database contains GO terms that describe biological functions of genes. Previous methods for comparing GO terms have relied on the fact that GO terms are organized into a tree structure. Under this paradigm, the locations of tw...
Journal of computational biology : a journal of computational molecular cell biology
Aug 22, 2018
Construction of phylogenetic trees and networks for extant species from their characters represents one of the key problems in phylogenomics. While solution to this problem is not always uniquely defined and there exist multiple methods for tree/netw...