Laboratory investigation; a journal of technical methods and pathology
Feb 1, 2021
Cervical cancer is one of the most frequent cancers in women worldwide, yet the early detection and treatment of lesions via regular cervical screening have led to a drastic reduction in the mortality rate. However, the routine examination of screeni...
Laboratory investigation; a journal of technical methods and pathology
Jan 16, 2021
Data processing and learning has become a spearhead for the advancement of medicine, with pathology and laboratory medicine has no exception. The incorporation of scientific research through clinical informatics, including genomics, proteomics, bioin...
Laboratory investigation; a journal of technical methods and pathology
Aug 22, 2020
Radiomics has potential advantages in the noninvasive histopathological and molecular diagnosis of gliomas. We aimed to develop a novel image signature (IS)-based radiomics model to achieve multilayered preoperative diagnosis and prognostic stratific...
Laboratory investigation; a journal of technical methods and pathology
Aug 10, 2020
As defined by the World Health Organization, an endocrine disruptor is an exogenous substance or mixture that alters function(s) of the endocrine system and consequently causes adverse health effects in an intact organism, its progeny, or (sub)popula...
Laboratory investigation; a journal of technical methods and pathology
Jul 13, 2020
Hepatic steatosis droplet quantification with histology biopsies has high clinical significance for risk stratification and management of patients with fatty liver diseases and in the decision to use donor livers for transplantation. However, patholo...
Laboratory investigation; a journal of technical methods and pathology
May 29, 2020
A pathological evaluation is one of the most important methods for the diagnosis of malignant lymphoma. A standardized diagnosis is occasionally difficult to achieve even by experienced hematopathologists. Therefore, established procedures including ...
Laboratory investigation; a journal of technical methods and pathology
Sep 30, 2019
Bone marrow aspirate (BMA) differential cell counts (DCCs) are critical for the classification of hematologic disorders. While manual counts are considered the gold standard, they are labor intensive, time consuming, and subject to bias. A reliable a...
Laboratory investigation; a journal of technical methods and pathology
Jun 20, 2019
As part of routine histological grading, for every invasive breast cancer the mitotic count is assessed by counting mitoses in the (visually selected) region with the highest proliferative activity. Because this procedure is prone to subjectivity, th...
Laboratory investigation; a journal of technical methods and pathology
Jun 14, 2019
Microvascularity is highly correlated with the grading and subtyping of gliomas, making this one of its most important histological features. Accurate quantitative analysis of microvessels is helpful for the development of a targeted therapy for anti...
Laboratory investigation; a journal of technical methods and pathology
Feb 15, 2019
Accumulation of abnormal tau in neurofibrillary tangles (NFT) occurs in Alzheimer disease (AD) and a spectrum of tauopathies. These tauopathies have diverse and overlapping morphological phenotypes that obscure classification and quantitative assessm...