AIMC Topic: Administration, Inhalation

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Step up to triple therapy versus switch to dual bronchodilator therapy in patients with COPD on an inhaled corticosteroid/long-acting β-agonist: post-hoc analyses of KRONOS.

Respiratory research May 8, 2025
BACKGROUND: In people with chronic obstructive pulmonary disease (COPD) on inhaled corticosteroid/long-acting β-agonist (ICS/LABA) therapy, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommends stepping up to ICS/long-acting mu...
Muscarinic Antagonists Adrenal Cortex Hormones Administration, Inhalation Bronchodilator Agents Double-Blind Method Drug Therapy, Combination Drug Substitution Adrenergic beta-2 Receptor Agonists Humans Female Aged Pulmonary Disease, Chronic Obstructive Male Middle Aged Treatment Outcome Drug Combinations
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Hyperpolarized Gas Imaging in Lung Diseases: Functional and Artificial Intelligence Perspective.

Academic radiology Jan 16, 2024
Pathophysiologic changes in lung diseases are often accompanied by changes in ventilation and gas exchange. Comprehensive evaluation of lung function cannot be obtained through chest X-ray and computed tomography. Proton-based lung MRI is particularl...
Magnetic Resonance Imaging Lung Diseases Administration, Inhalation Xenon Isotopes Humans Artificial Intelligence
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Experimental drugs in clinical trials for COPD: artificial intelligence via machine learning approach to predict the successful advance from early-stage development to approval.

Expert opinion on investigational drugs Jul 6, 2023
INTRODUCTION: Therapeutic advances in drug therapy of chronic obstructive pulmonary disease (COPD) really effective in suppressing the pathological processes underlying the disease deterioration are still needed. Artificial Intelligence (AI) via Mach...
Pulmonary Disease, Chronic Obstructive Bayes Theorem Muscarinic Antagonists Administration, Inhalation Bronchodilator Agents Humans Adrenergic beta-2 Receptor Agonists Artificial Intelligence Machine Learning
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RespiraTox - Development of a QSAR model to predict human respiratory irritants.

Regulatory toxicology and pharmacology : RTP Nov 30, 2021
Respiratory irritation is an important human health endpoint in chemical risk assessment. There are two established modes of action of respiratory irritation, 1) sensory irritation mediated by the interaction with sensory neurons, potentially stimula...
Irritants Machine Learning Risk Assessment Quantitative Structure-Activity Relationship Animal Testing Alternatives Administration, Inhalation Respiratory System
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In vitro and in vivo performance modelling and optimisation of different dry powder inhalers: A complementary study of neural networks, genetic algorithms and decision trees.

International journal of clinical practice Nov 11, 2020
INTRODUCTION: Aerosol delivery from DPIs could be affected by different factors. This study aimed to evaluate and predict the effects of different factors on drug delivery from DPIs.
Dry Powder Inhalers Bronchodilator Agents Neural Networks, Computer Algorithms Decision Trees Administration, Inhalation Humans
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Plasma and cerebrospinal fluid population pharmacokinetic modeling and simulation of meropenem after intravenous and intrathecal administration in postoperative neurosurgical patients.

Diagnostic microbiology and infectious disease Aug 17, 2018
Combined intravenous and local intrathecal administration of meropenem in patients after craniotomy is widely used to treat intracranial infections. However, the optimal dosing regimen of meropenem has not been investigated, posing a risk to treatmen...
Neurosurgical Procedures Administration, Inhalation Male Humans Surgical Wound Infection Beijing Anti-Bacterial Agents Microbial Sensitivity Tests Meropenem Plasma Female Administration, Intravenous Time Factors Cerebrospinal Fluid
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Aerosol delivery during spontaneous breathing with different types of nebulizers- in vitro/ex vivo models evaluation.

Pulmonary pharmacology & therapeutics Dec 19, 2017
BACKGROUND: Nebulizers for spontaneous breathing have been evaluated through different study designs. There are limitations in simulated bench models related to patient and nebulizer factors. The aim of this study was to determine the correlation of ...
Drug Delivery Systems Male Equipment Design Models, Biological Respiration Administration, Inhalation Aerosols Albuterol Exhalation Humans Bronchodilator Agents Female Inhalation Young Adult Nebulizers and Vaporizers
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Efficacy and safety of lebrikizumab in adult patients with mild-to-moderate asthma not receiving inhaled corticosteroids.

Respiratory medicine Dec 13, 2017
BACKGROUND: Asthma is a heterogeneous and complex disease in both its clinical course and response to treatment. IL-13 is central to Type 2 inflammation and contributes to many features of asthma. In a previous Phase 2 study, lebrikizumab, an anti-IL...
Male Middle Aged Glucocorticoids Severity of Illness Index Female Anti-Asthmatic Agents Adult Humans Asthma Treatment Failure Quinolines Double-Blind Method Injections, Subcutaneous Administration, Inhalation Forced Expiratory Volume Treatment Outcome Acetates Cyclopropanes Sulfides Antibodies, Monoclonal
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A randomised, phase III trial of once-daily fluticasone furoate/vilanterol 100/25 μg versus once-daily vilanterol 25 μg to evaluate the contribution on lung function of fluticasone furoate in the combination in patients with COPD.

Respiratory medicine Dec 2, 2016
BACKGROUND: The contribution of fluticasone furoate (FF) on lung function in the FF/vilanterol (VI) 100/25 μg combination has been demonstrated numerically, but not statistically.
Androstadienes Adrenergic beta-2 Receptor Agonists Benzyl Alcohols Chlorobenzenes Drug Administration Schedule Kaplan-Meier Estimate Administration, Inhalation Pulmonary Disease, Chronic Obstructive Male Middle Aged Glucocorticoids Quality of Life Drug Combinations Humans Double-Blind Method Female Forced Expiratory Volume Aged Adult
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Energy Efficient Monitoring of Metered Dose Inhaler Usage.

Journal of medical systems Oct 29, 2016
Life-long chronic inflammatory diseases of the airways, such as asthma and Chronic Obstructive Pulmonary Disease, are very common worldwide, affecting people of all ages, race and gender. One of the most important aspects for the effective management...
Monitoring, Ambulatory Administration, Inhalation Bronchodilator Agents Data Compression Humans Medication Adherence Support Vector Machine Wireless Technology Metered Dose Inhalers
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