AIMC Topic: Aging

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Addressing the Black Box of AI-A Model and Research Agenda on the Co-constitution of Aging and Artificial Intelligence.

The Gerontologist
Algorithmic technologies and (large) data infrastructures, often referred to as Artificial Intelligence (AI), have received increasing attention from gerontological research in the last decade. Although there is much literature that dissects and expl...

Biomarker signatures associated with ageing free of major chronic diseases: results from a population-based sample of the EPIC-Potsdam cohort.

Age and ageing
BACKGROUND: A number of biomarkers denoting various pathophysiological pathways have been implicated in the aetiology and risk of age-related diseases. Hence, the combined impact of multiple biomarkers in relation to ageing free of major chronic dise...

Dissecting unique and common variance across body and brain health indicators using age prediction.

Human brain mapping
Ageing is a heterogeneous multisystem process involving different rates of decline in physiological integrity across biological systems. The current study dissects the unique and common variance across body and brain health indicators and parses inte...

AgeAnnoMO: a knowledgebase of multi-omics annotation for animal aging.

Nucleic acids research
Aging entails gradual functional decline influenced by interconnected factors. Multiple hallmarks proposed as common and conserved underlying denominators of aging on the molecular, cellular and systemic levels across multiple species. Thus, understa...

Association between Resting Heart Rate and Machine Learning-Based Brain Age in Middle- and Older-Age.

The journal of prevention of Alzheimer's disease
BACKGROUND: Resting heart rate (RHR), has been related to increased risk of dementia, but the relationship between RHR and brain age is unclear.

Spatial mapping of human hematopoiesis at single-cell resolution reveals aging-associated topographic remodeling.

Blood
The spatial anatomy of hematopoiesis in the bone marrow (BM) has been extensively studied in mice and other preclinical models, but technical challenges have precluded a commensurate exploration in humans. Institutional pathology archives contain tho...

Whole-brain radiotherapy associated with structural changes resembling aging as determined by anatomic surface-based deep learning.

Neuro-oncology
BACKGROUND: Brain metastases are the most common intracranial tumors in adults and are associated with significant morbidity and mortality. Whole-brain radiotherapy (WBRT) is used frequently in patients for palliation, but can result in neurocognitiv...

Exploring artificial intelligence from a clinical perspective: A comparison and application analysis of two facial age predictors trained on a large-scale Chinese cosmetic patient database.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
BACKGROUND: Age prediction powered by artificial intelligence (AI) can be used as an objective technique to assess the cosmetic effect of rejuvenation surgery. Existing age-estimation models are trained on public datasets with the Caucasian race as t...

A quick and reliable image-based AI algorithm for evaluating cellular senescence of gastric organoids.

Cancer biology & medicine
OBJECTIVE: Organoids are a powerful tool with broad application prospects in biomedicine. Notably, they provide alternatives to animal models for testing potential drugs before clinical trials. However, the number of passages for which organoids main...