AIMC Topic: Algorithms

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A comparison of random forest variable selection methods for regression modeling of continuous outcomes.

Briefings in bioinformatics
Random forest (RF) regression is popular machine learning method to develop prediction models for continuous outcomes. Variable selection, also known as feature selection or reduction, involves selecting a subset of predictor variables for modeling. ...

MAEST: accurately spatial domain detection in spatial transcriptomics with graph masked autoencoder.

Briefings in bioinformatics
Spatial transcriptomics (ST) technology provides gene expression profiles with spatial context, offering critical insights into cellular interactions and tissue architecture. A core task in ST is spatial domain identification, which involves detectin...

Ensemble learning based on matrix completion improves microbe-disease association prediction.

Briefings in bioinformatics
Microbes have a profound impact on human health. Identifying disease-associated microbes would provide helpful guidance for drug development and disease treatment. Through an enormous experimental effort, limited disease-associated microbes have been...

PharaCon: a new framework for identifying bacteriophages via conditional representation learning.

Bioinformatics (Oxford, England)
MOTIVATION: Identifying bacteriophages (phages) within metagenomic sequences is essential for understanding microbial community dynamics. Transformer-based foundation models have been successfully employed to address various biological challenges. Ho...

COME: contrastive mapping learning for spatial reconstruction of single-cell RNA sequencing data.

Bioinformatics (Oxford, England)
MOTIVATION: Single-cell RNA sequencing (scRNA-seq) enables high-throughput transcriptomic profiling at single-cell resolution. The inherent spatial location is crucial for understanding how single cells orchestrate multicellular functions and drive d...

MOSTPLAS: a self-correction multi-label learning model for plasmid host range prediction.

Bioinformatics (Oxford, England)
MOTIVATION: Plasmids play an essential role in horizontal gene transfer, aiding their host bacteria in acquiring beneficial traits like antibiotic and metal resistance. There exist some plasmids that can transfer, replicate, or persist in multiple or...

An Approach to Predict Intraocular Diseases by Machine Learning Based on Vitreous Humor Immune Mediator Profile.

Investigative ophthalmology & visual science
PURPOSE: This study aimed to elucidate whether machine learning algorithms applied to vitreous levels of immune mediators predict the diagnosis of 12 representative intraocular diseases, and identify immune mediators driving the predictive power of m...

Artificial Intelligence Versus Rules-Based Approach for Segmenting NonPerfusion Area in a DRCR Retina Network Optical Coherence Tomography Angiography Dataset.

Investigative ophthalmology & visual science
PURPOSE: Loss of retinal perfusion is associated with both onset and worsening of diabetic retinopathy (DR). Optical coherence tomography angiography is a noninvasive method for measuring the nonperfusion area (NPA) and has promise as a scalable scre...

Automated proximal coronary artery calcium identification using artificial intelligence: advancing cardiovascular risk assessment.

European heart journal. Cardiovascular Imaging
AIMS: Identification of proximal coronary artery calcium (CAC) may improve prediction of major adverse cardiac events (MACE) beyond the CAC score, particularly in patients with low CAC burden. We investigated whether the proximal CAC can be detected ...

Artificial intelligence-derived electrocardiographic aging and risk of atrial fibrillation: a multi-national study.

European heart journal
BACKGROUND AND AIMS: Artificial intelligence (AI) algorithms in 12-lead electrocardiogram (ECG) provides promising age prediction methods. This study investigated whether the discrepancy between ECG-derived AI-predicted age (AI-ECG age) and chronolog...