Chromatin architecture plays an important role in gene regulation. Recent advances in super-resolution microscopy have made it possible to measure chromatin 3D structure and transcription in thousands of single cells. However, leveraging these comple...
Pre-mRNA splicing is a key controller of human gene expression. Disturbances in splicing due to mutation lead to dysregulated protein expression and contribute to a substantial fraction of human disease. Several classes of splicing modulator compound...
Neural networks : the official journal of the International Neural Network Society
Jun 5, 2021
Biological motor control mechanisms (e.g., central pattern generators (CPGs), sensory feedback, reflexes, and motor learning) play a crucial role in the adaptive locomotion of animals. However, the interaction and integration of these mechanisms - ne...
The international journal of medical robotics + computer assisted surgery : MRCAS
Jun 5, 2021
BACKGROUND: Handheld surgical robots offer functionalities, such as active guidance, tremor suppression and force reflection, for surgeons to enhance their skill in manipulating surgical tools during medical intervention. In orthopedic surgery, the r...
Cardiomegaly is the main imaging finding for canine heart diseases. There are many advances in the field of medical diagnosing based on imaging with deep learning for human being. However there are also increasing realization of the potential of usin...
In order to increase the compatibility between underwater robots and the underwater environment and inspired by the coconut octopus's underwater bipedal walking, a method was proposed for bipedal walking for an underwater soft robot based on a spring...
IEEE transactions on image processing : a publication of the IEEE Signal Processing Society
Jun 3, 2021
In this paper, we propose a large-scale video based animal counting dataset collected by drones (AnimalDrone) for agriculture and wildlife protection. The dataset consists of two subsets, i.e., PartA captured on site by drones and PartB collected fro...
I outline how over my career as a protein scientist Machine Learning has impacted my area of science and one of my pastimes, chess, where there are some interesting parallels. In 1968, modelling of three-dimensional structures was initiated based on ...
Using the Cap Analysis of Gene Expression (CAGE) technology, the FANTOM5 consortium provided one of the most comprehensive maps of transcription start sites (TSSs) in several species. Strikingly, ~72% of them could not be assigned to a specific gene ...
Technological advances have enabled us to profile multiple molecular layers at unprecedented single-cell resolution and the available datasets from multiple samples or domains are growing. These datasets, including scRNA-seq data, scATAC-seq data and...
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