AIMC Topic: Animals

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The research on artificial intelligence-based Deer Velvet Antler traceability model based on emergent data features.

Talanta
Deer velvet antler(DVA) is highly valued for its nutritional properties, but its complex origins and widespread adulteration in the market have led to significant quality discrepancies. Therefore, this study aims to establish an efficient and accurat...

Machine learning based diagnostics of veterinary cancer on ultrasound and optical imaging data.

The veterinary quarterly
Study advances current diagnostic efficiency of canine/feline (sub-)cutaneous tumors using machine learning and multimodal imaging data. White light (WL), fluorescence (FL) and ultrasound (US) imaging were combined into hybrid approaches to different...

Reduction of photobleaching effects in photoacoustic imaging using noise agnostic, platform-flexible deep-learning methods.

Journal of biomedical optics
SIGNIFICANCE: Molecular photoacoustic (PA) imaging with exogenous dyes faces a significant challenge due to the photobleaching of the dye that can compromise tissue visualization, particularly in 3D imaging. Addressing this limitation can revolutioni...

Discovery of novel diagnostic biomarkers of hepatocellular carcinoma associated with immune infiltration.

Annals of medicine
OBJECTIVE: Diagnosis of hepatocellular carcinoma (HCC) remains challenging for clinicians. Machine learning approaches and big data analyses are viable strategies for identifying HCC diagnostic markers.

High-Quality CEST Mapping With Lorentzian-Model Informed Neural Representation.

IEEE transactions on bio-medical engineering
Chemical Exchange Saturation Transfer (CEST) MRI has demonstrated its remarkable ability to enhance the detection of macromolecules and metabolites with low concentrations. While CEST mapping is essential for quantifying molecular information, conven...

Development of potent humanized TNFα inhibitory nanobodies for therapeutic applications in TNFα-mediated diseases.

mAbs
Tumor necrosis factor-alpha (TNFα) is a key pro-inflammatory cytokine implicated in the pathogenesis of numerous inflammatory and autoimmune diseases, including rheumatoid arthritis, inflammatory bowel disease, and neurodegenerative disorders such as...

An antibody developability triaging pipeline exploiting protein language models.

mAbs
Therapeutic monoclonal antibodies (mAbs) are a successful class of biologic drugs that are frequently selected from phage display libraries and transgenic mice that produce fully human antibodies. However, binding affinity to the correct epitope is n...

Machine learning-assisted design of immunomodulatory lipid nanoparticles for delivery of mRNA to repolarize hyperactivated microglia.

Drug delivery
Regulating inflammatory microglia presents a promising strategy for treating neurodegenerative and autoimmune disorders, yet effective therapeutic agents delivery to these cells remains a challenge. This study investigates modified lipid nanoparticle...

Key RNA-binding proteins in renal fibrosis: a comprehensive bioinformatics and machine learning framework for diagnostic and therapeutic insights.

Renal failure
BACKGROUND: Renal fibrosis is a critical factor in chronic kidney disease progression, with limited diagnostic and therapeutic options. Emerging evidence suggests RNA-binding proteins (RBPs) are pivotal in regulating cellular mechanisms underlying fi...

Dissecting Shared Genetic Architecture of Thoracic Aortic Aneurysm and Aortic Related Traits and Identifying SplA/Ryanodine Receptor Domain and SOCS Box Containing 1 Involved in Smooth Muscle Phenotype Switching and Cell Senescence Through Alternative Splicing.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Machine learning was employed to annotate images of the thoracic aorta, resulting in the identification of additional thoracic-related targets. However, genetic evaluation of the associations among thoracic aortic traits and their shared genes is lac...