AIMC Topic: Animals

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Rapid Fluorescence Lifetime Imaging through One-Dimensional Deep Learning Optimization.

Analytical chemistry
Traditional fluorescence lifetime imaging (FLIM) provides valuable quantitative insights for biomedical and molecular biology research, but often relies on computationally intensive datafitting methods to extract meaningful metrics. To address this l...

Human and animal models for studying hemorrhagic shock.

Scandinavian journal of trauma, resuscitation and emergency medicine
BACKGROUND: Studying the physiological response to severe hemorrhage remains challenging in real-world patients. Animal and human models mitigate some of the challenges by facilitating controlled studies on hemorrhagic shock. Here, we comment on exis...

USP5-Mediated PD-L1 deubiquitination regulates immunotherapy efficacy in melanoma.

Journal of translational medicine
BACKGROUND: The role of post-translational modifications(PTMs) in PD-L1-mediated immune resistance and melanoma progression remains poorly understood.

Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions.

Molecular neurodegeneration
Recent advances in our understanding of non-cell-autonomous mechanisms in neurodegenerative diseases (NDDs) have highlighted microglial dysfunction as a core driver of disease progression. Conditions such as Alzheimer's disease (AD), amyotrophic late...

Automated tick classification using deep learning and its associated challenges in citizen science.

Scientific reports
Lyme borreliosis and tick-borne encephalitis significantly impact public health in Europe, transmitted primarily by endemic tick species. The recent introduction of exotic tick species into northern Europe via migratory birds, imported animals, and t...

A bird species occurrence dataset from passive audio recordings across dense urban areas in Gothenburg, Sweden.

Scientific data
Bird species occurrence datasets are a valuable resource for understanding the effects of urbanization on various biotic conditions (e.g., species occupancy and richness). Existing datasets offer promising opportunities to explore variations among ci...

Application of machine learning models for zooplankton abundance prediction in ponds of Southeastern Coastal Regions in Bangladesh.

Environmental monitoring and assessment
Zooplankton abundance prediction in surface water bodies is crucial because they reflect ecosystem health and have role in aquatic food webs and nutrient cycling. This study examined the applicability of machine learning algorithms to estimate zoopla...

TRIM29 alleviates intervertebral disc degeneration through the PI3K/AKT/mTOR pathway.

Scientific reports
Intervertebral disc degeneration (IDD), a prevalent spinal condition linked to low back pain, has substantial genetic components, necessitating deeper understanding of its mechanisms. This study categorized nucleus pulposus cell (NPC) populations and...

Biologically-informed excitatory and inhibitory ratio for robust spiking neural network training.

Scientific reports
Spiking neural networks drawing inspiration from biological constraints of the brain promise an energy-efficient paradigm for artificial intelligence. However, challenges exist in identifying guiding principles to train these networks in a robust fas...

Decoding tissue complexity: multiscale mapping of chemistry-structure-function relationships through advanced visualization technologies.

Journal of materials chemistry. B
Comprehensively acquiring biological tissue information is pivotal for advancing our understanding of biological systems, elucidating disease mechanisms, and developing innovative clinical strategies. Biological tissues, as nature's archetypal biomat...