Computer methods and programs in biomedicine
Jun 11, 2025
BACKGROUND: Infections caused by carbapenem resistant gram-negative bacilli (CRGNB) are associated with high mortality and pose a great challenge for clinical treatment. We aim to identify patients at high risk for CRGNB as early as possible and aler...
Indigenous phages play a key role in the spread of extracellular antibiotic resistance genes (eARGs), and micro/nanocontaminants can exacerbate this process. However, the specific roles and mechanisms of phage communities in this process are still no...
(Fluoro)quinolones (FQs) pose significant threats to public health due to their widespread use and persistence in food and water sources. Given the extensive variety of FQs, testing each compound individually is prohibitively expensive and time-consu...
The prevalence and spread of carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a global public health problem. This study aims to identify the risk factors of CRPA infection and construct a machine learning model to provide a prediction tool for ...
The quest for solutions to infectious diseases and life-debilitating disease states has been ongoing for centuries now. Natural products researches have revealed bioactive compounds of plant and microbial origin that offer solutions to health conditi...
is a highly versatile and resilient pathogen that can infect different tissues and rapidly develop resistance to multiple drugs. Ceftazidime-avibactam (CZA) is an antibiotic often used to treat multidrug-resistant infections; however, the knowledge ...
ConspectusThe escalating threat of antimicrobial resistance (AMR) poses a significant global health crisis, potentially surpassing cancer as a leading cause of death by 2050. Traditional antibiotic discovery methods have not kept pace with the rapidl...
The rapid advancement of artificial intelligence (AI) has enabled de novo design of functional proteins, circumventing the reliance on natural templates or sequencing databases. However, current protein design models are ineffective in generating pro...
Bacterial sepsis remains a leading cause of death globally, exacerbated by the rise of multidrug resistance (MDR). Host-directed therapy (HDT) has emerged as a promising nonantibiotic approach to combat infections; thus, multiple HDT targets have bee...
Clinical informatics has emerged as a valuable approach to enhance antimicrobial stewardship programs in healthcare settings. By integrating information technology with healthcare services, hospitals can systematically collect, store, and utilize med...
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