AIMC Topic: Anti-Infective Agents
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Recent Progress in Machine Learning-based Prediction of Peptide Activity for Drug Discovery.
Current topics in medicinal chemistry
Jan 1, 2019
Over the past decades, peptide as a therapeutic candidate has received increasing attention in drug discovery, especially for antimicrobial peptides (AMPs), anticancer peptides (ACPs) and antiinflammatory peptides (AIPs). It is considered that the pe...
Deep learning improves antimicrobial peptide recognition.
Bioinformatics (Oxford, England)
Aug 15, 2018
MOTIVATION: Bacterial resistance to antibiotics is a growing concern. Antimicrobial peptides (AMPs), natural components of innate immunity, are popular targets for developing new drugs. Machine learning methods are now commonly adopted by wet-laborat...
modlAMP: Python for antimicrobial peptides.
Bioinformatics (Oxford, England)
Sep 1, 2017
SUMMARY: We have implemented the lecular esign aboratory's nti icrobial eptides package ( ), a Python-based software package for the design, classification and visual representation of peptide data. modlAMP offers functions for molecular descriptor c...
A Fresh Shine onCystic Fibrosis Inhalation Therapy: Antimicrobial Synergy of Polymyxin B in Combination with Silver Nanoparticles.
Journal of biomedical nanotechnology
Apr 1, 2017
This in vitro study aimed to investigate the synergistic antibacterial activity of polymyxin B in combination with 2 nm silver nanoparticles (NPs) against Gram-negative pathogens commonly isolated from the cystic fibrosis (CF) lung. The in vitro syne...
Potential of Piper betle extracts on inhibition of oral pathogens.
Drug discoveries & therapeutics
Jan 1, 2017
In the present study, antimicrobial activity of Piper betle crude ethanol extract against 4 strains of oral pathogens; Candida albicans DMST 8684, C. albicans DMST 5815, Streptococcus gordonii DMST 38731 and Streptococcus mutans DMST 18777 was compar...
Antimicrobial Activity and Biocompatibility of the Psidium cattleianum Extracts for Endodontic Purposes.
Brazilian dental journal
Jan 1, 2017
Psidium cattleianum (PC) has been displaying inhibitory effect against a variety of microorganisms, but this effect has not yet been tested against endodontic pathogens. The aim of this study was to evaluate the antimicrobial activity and biocompatib...
Dilemma: Correlation Between Serum Level of Hepcidin and IL-6 in Anemic Myeloma Patients.
Medical archives (Sarajevo, Bosnia and Herzegovina)
Dec 1, 2016
INTRODUCTION: Anemia occurs in 60% to 80 % of patients with newly diagnosed myeloma multiplex (MM). The cause of anemia in MM is probably multi factorial and involved among the others hepcidin and some cytokines, especially interleukine-6. Anemia in ...
Evaluation of the Antimicrobial Functions of N-halamine Dental Unit Waterline Tubing for One Year.
The Journal of clinical dentistry
Mar 1, 2016
OBJECTIVES: The objective of this study was to test the biofilm-controlling properties of N-halamine antimicrobial dental unit waterline (DUWL) tubing (T) tubing, without recharging over one year, compared to a control line (C).
Ozone therapy as an adjuvant for endondontic protocols: microbiological - ex vivo study and citotoxicity analyses.
Journal of applied oral science : revista FOB
Jan 1, 2016
OBJECTIVES: This study evaluated the antimicrobial efficacy of ozone therapy in teeth contaminated with Pseudomonas aeruginosa, Enterococcus faecalis, and Staphylococcus aureus using a mono-species biofilm model. Parallel to this, the study aimed to ...
Artificial Neural Network Analysis of Pharmacokinetic and Toxicity Properties of Lead Molecules for Dengue Fever, Tuberculosis and Malaria.
Current computer-aided drug design
Jan 1, 2016
Poor pharmacokinetic and toxicity profiles are major reasons for the low rate of advancing lead drug candidates into efficacy studies. The In-silico prediction of primary pharmacokinetic and toxicity properties in the drug discovery and development p...
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