AIMC Topic: Arthritis, Rheumatoid
Clear Filters Showing 81 to 90 of 117 articles
eDRAM: Effective early disease risk assessment with matrix factorization on a large-scale medical database: A case study on rheumatoid arthritis.
PloS one
Nov 26, 2018
Recently, a number of analytical approaches for probing medical databases have been developed to assist in disease risk assessment and to determine the association of a clinical condition with others, so that better and intelligent healthcare can be ...
RNA-seq analysis reveals different gene ontologies and pathways in rheumatoid arthritis and Kashin-Beck disease.
International journal of rheumatic diseases
Sep 5, 2018
AIMS: To understand the pathogenesis of cartilage damage in Kashin-Beck disease (KBD) and rheumatoid arthritis (RA) which similar clinical symptoms.
Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data.
Arthritis & rheumatology (Hoboken, N.J.)
Apr 2, 2018
OBJECTIVE: In this study, we sought to refine histologic scoring of rheumatoid arthritis (RA) synovial tissue by training with gene expression data and machine learning.
Glycomics meets artificial intelligence - Potential of glycan analysis for identification of seropositive and seronegative rheumatoid arthritis patients revealed.
Clinica chimica acta; international journal of clinical chemistry
Feb 25, 2018
In this study, one hundred serum samples from healthy people and patients with rheumatoid arthritis (RA) were analyzed. Standard immunoassays for detection of 10 different RA markers and analysis of glycan markers on antibodies in 10 different assay ...
Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.
European journal of medicinal chemistry
Dec 28, 2017
Bruton's tyrosine kinase (Btk) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) and Fcγ receptor (FcR) signaling pathways, which makes it a uniquely attractive target for the treatment of autoimmune diseases, such as rheum...
Haplorhini
Cell Line
Arthritis, Rheumatoid
Protein-Tyrosine Kinases
Dogs
Pyrroles
Rats
Structure-Activity Relationship
Humans
Microsomes, Liver
Cell Proliferation
Models, Molecular
Animals
Rats, Sprague-Dawley
Protein Kinase Inhibitors
Drug Design
Molecular Structure
Dose-Response Relationship, Drug
Pyrimidines
Mice
Agammaglobulinaemia Tyrosine Kinase
Jobelyn attenuates inflammatory responses and neurobehavioural deficits associated with complete Freund-adjuvant-induced arthritis in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Dec 27, 2017
Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the physical and psychosocial wellbeing of the patients and a major cause of work disability. Current drugs for its treatment only provide palliative effect, as cure for the dis...
Phase 1b Study of the Safety, Pharmacokinetics, and Disease-related Outcomes of the Matrix Metalloproteinase-9 Inhibitor Andecaliximab in Patients With Rheumatoid Arthritis.
Clinical therapeutics
Dec 26, 2017
PURPOSE: Andecaliximab (GS-5745) is a highly selective monoclonal antibody against matrix metalloproteinase-9 (MMP9), a proteolytic enzyme implicated in the pathogenesis of rheumatoid arthritis (RA). This study assessed the safety and pharmacokinetic...
Characterizing Autoimmune Disease-associated Diffuse Large B-cell Lymphoma in a SEER-Medicare Cohort.
Clinical lymphoma, myeloma & leukemia
Dec 2, 2017
BACKGROUND: Severe immune dysregulation such as seen in autoimmune (AI) disease is known to act as a significant risk factor for diffuse large B-cell lymphoma (DLBCL). However, little is known about the demographics or clinical outcomes of DLBCL that...
Development and validation of a multivariate predictive model for rheumatoid arthritis mortality using a machine learning approach.
Scientific reports
Aug 31, 2017
We developed and independently validated a rheumatoid arthritis (RA) mortality prediction model using the machine learning method Random Survival Forests (RSF). Two independent cohorts from Madrid (Spain) were used: the Hospital Clínico San Carlos RA...
The Economic Burden of ACPA-Positive Status Among Patients with Rheumatoid Arthritis.
Journal of managed care & specialty pharmacy
Jul 17, 2017
BACKGROUND: Anticitrullinated protein antibodies (ACPAs) are serological biomarkers associated with early, rapidly progressing rheumatoid arthritis (RA), including more severe disease and joint damage. ACPA testing has become a routine tool for RA di...
Don't Miss the Future of Medicine
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.
Subscribe NowPopular Topics
- Machine Learning 31137
- Neural Networks, Computer 29769
- Algorithms 26908
- Deep Learning 26418
- Artificial Intelligence 24354
- Robotics 13322
- Image Processing, Computer-Assisted 9552
- Retrospective Studies 9136
- Magnetic Resonance Imaging 6198
- Reproducibility of Results 5602
- Tomography, X-Ray Computed 4778
- Support Vector Machine 4695
- Computational Biology 4246
- Brain 4056
- Computer Simulation 3887
Recent Journals
- Scientific reports 6082
- Sensors (Basel, Switzerland) 4794
- PloS one 4044
- Neural networks : the official journal of the International Neural Network Society 2930
- Computational intelligence and neuroscience 1931
- Computers in biology and medicine 1868
- Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 1686
- Studies in health technology and informatics 1278
- IEEE journal of biomedical and health informatics 1137
- Journal of chemical information and modeling 1006
- Nature communications 959
- Computer methods and programs in biomedicine 883
- Bioinformatics (Oxford, England) 862
- Briefings in bioinformatics 853
- IEEE transactions on neural networks and learning systems 829