AIMC Topic: Axons

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Computational analysis of non-invasive deep brain stimulation based on interfering electric fields.

Physics in medicine and biology Dec 5, 2019
Neuromodulation modalities are used as effective treatments for some brain disorders. Non-invasive deep brain stimulation (NDBS) via temporally interfering electric fields has emerged recently as a non-invasive strategy for electrically stimulating d...
Electrodes Deep Brain Stimulation Axons Electricity Humans Neural Networks, Computer Models, Neurological
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Measurement-oriented deep-learning workflow for improved segmentation of myelin and axons in high-resolution images of human cerebral white matter.

Journal of neuroscience methods Aug 1, 2019
BACKGROUND: Standard segmentation of high-contrast electron micrographs (EM) identifies myelin accurately but does not translate easily into measurements of individual axons and their myelin, even in cross-sections of parallel fibers. We describe aut...
Axons Image Interpretation, Computer-Assisted Microscopy, Electron White Matter Humans Workflow Deep Learning Autopsy Cerebrum Myelin Sheath
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Deep learning for high-throughput quantification of oligodendrocyte ensheathment at single-cell resolution.

Communications biology Mar 26, 2019
High-throughput quantification of oligodendrocyte myelination is a challenge that, if addressed, would facilitate the development of therapeutics to promote myelin protection and repair. Here, we established a high-throughput method to assess oligode...
Brain Myelin Sheath Rats Animals Oligodendrocyte Precursor Cells Rats, Sprague-Dawley Axons Oligodendroglia Cell Differentiation Deep Learning Nanofibers Data Accuracy Single-Cell Analysis
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Morphometric analysis of peripheral myelinated nerve fibers through deep learning.

Journal of the peripheral nervous system : JPNS Dec 11, 2018
Irrespective of initial causes of neurological diseases, these disorders usually exhibit two key pathological changes-axonal loss or demyelination or a mixture of the two. Therefore, vigorous quantification of myelin and axons is essential in studyin...
Animals Deep Learning Mice Axons Pattern Recognition, Automated Nerve Fibers, Myelinated Mice, Inbred C57BL Mice, Knockout Microscopy
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Fibroblast growth factor23 is associated with axonal integrity and neural network architecture in the human frontal lobes.

PloS one Sep 7, 2018
Elevated levels of FGF23 in individuals with chronic kidney disease (CKD) are associated with adverse health outcomes, such as increased mortality, large vessel disease, and reduced white matter volume, cardiovascular and cerebrovascular events. Apar...
Risk Factors Male Cardiovascular Diseases Frontal Lobe Middle Aged Axons Humans Cohort Studies Endothelium, Vascular Neural Networks, Computer Renal Insufficiency, Chronic Vascular Stiffness White Matter Female Magnetic Resonance Imaging Fibroblast Growth Factor-23 Vascular Calcification Fibroblast Growth Factors
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Assessing functional connectivity across 3D tissue engineered axonal tracts using calcium fluorescence imaging.

Journal of neural engineering Jun 1, 2018
OBJECTIVE: Micro-tissue engineered neural networks (micro-TENNs) are anatomically-inspired constructs designed to structurally and functionally emulate white matter pathways in the brain. These 3D neural networks feature long axonal tracts spanning d...
Delta Rhythm Neural Pathways Entropy Theta Rhythm Rats Neurons Calcium Axons Pregnancy Neuroimaging Female Tissue Engineering Animals Cerebral Cortex Fluorescence Neural Networks, Computer
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AxonDeepSeg: automatic axon and myelin segmentation from microscopy data using convolutional neural networks.

Scientific reports Feb 28, 2018
Segmentation of axon and myelin from microscopy images of the nervous system provides useful quantitative information about the tissue microstructure, such as axon density and myelin thickness. This could be used for instance to document cell morphom...
Axons Automation Neural Networks, Computer Software Animals Image Processing, Computer-Assisted Mice Microscopy Myelin Sheath
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Automated quantification of three-dimensional organization of fiber-like structures in biological tissues.

Biomaterials Nov 25, 2016
Fiber-like structures are prevalent in biological tissues, yet quantitative approaches to assess their three-dimensional (3D) organization are lacking. We develop 3D directional variance, as a quantitative biomarker of truly 3D fibrillar organization...
Fibrillar Collagens Axons Image Interpretation, Computer-Assisted Elastic Tissue Algorithms Humans Reproducibility of Results Machine Learning Sensitivity and Specificity Imaging, Three-Dimensional
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Automated tracing of myelinated axons and detection of the nodes of Ranvier in serial images of peripheral nerves.

Journal of microscopy Jun 12, 2015
The development of realistic neuroanatomical models of peripheral nerves for simulation purposes requires the reconstruction of the morphology of the myelinated fibres in the nerve, including their nodes of Ranvier. Currently, this information has to...
Datasets as Topic Ranvier's Nodes Algorithms Rats Microscopy, Electron Animals Supervised Machine Learning Peripheral Nerves Imaging, Three-Dimensional Axons Vagus Nerve
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Developmental time windows for axon growth influence neuronal network topology.

Biological cybernetics Jan 30, 2015
Early brain connectivity development consists of multiple stages: birth of neurons, their migration and the subsequent growth of axons and dendrites. Each stage occurs within a certain period of time depending on types of neurons and cortical layers....
Cell Division Time Models, Neurological Neural Networks, Computer Caenorhabditis elegans Axons Computer Simulation Neurogenesis Synapses Animals Embryo, Nonmammalian
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