As populations age, understanding cognitive decline and age-related diseases like dementia has become increasingly important. "SuperAgers," individuals over 65 with cognitive abilities similar to those in their 40s, provide a unique perspective on co...
The diagnostic accuracy for coronary heart disease (CHD) needs to be improved. Some studies have indicated that klotho protein levels upon admission comprise an independent risk factor for CHD and have clinical value for predicting CHD. This study ai...
BACKGROUND: Branched-chain amino acids (BCAA) metabolism is significantly associated with osteoarthritis (OA), but the specific mechanism of BCAA related genes (BCAA-RGs) in OA is still unclear. Therefore, this research intended to identify potential...
OBJECTIVES: To develop a deep learning network for extracting features from the blood-supplying regions of the lenticulostriate artery (LSA) and to establish these features as an imaging biomarker for the comprehensive assessment of the lenticulostri...
Atherosclerosis is a chronic inflammatory disease, this study aims to investigate the immune landscape in carotid atherosclerotic plaque formation and explore diagnostic biomarkers of lactylation-associated genes, so as to gain new insights into unde...
Coronary artery disease (CAD) is a worldwide leading cause of death. Considering that 20%-40% of patients with CAD have a long asymptomatic period of atherosclerosis, it has become urgent to explore the feasibility of diagnosing CAD at an early stage...
BACKGROUND: To develop a predictive model for bone destruction in patients with rheumatoid arthritis (RA), based on the characteristics of plasma metabolites and common clinical indicators.
Friedreich ataxia (FRDA) is a rare, inherited progressive movement disorder for which there is currently no cure. The field urgently requires more sensitive, objective, and clinically relevant biomarkers to enhance the evaluation of treatment efficac...
Machine learning algorithms that integrate multiple biomarkers are increasingly used in disease detection, yet economic considerations are often overlooked. Medial vascular calcification (mVC), a pathology associated with elevated cardiovascular risk...
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