AIMC Topic: Biomarkers

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An Approach to Predict Intraocular Diseases by Machine Learning Based on Vitreous Humor Immune Mediator Profile.

Investigative ophthalmology & visual science
PURPOSE: This study aimed to elucidate whether machine learning algorithms applied to vitreous levels of immune mediators predict the diagnosis of 12 representative intraocular diseases, and identify immune mediators driving the predictive power of m...

Predicting amyloid beta accumulation in cognitively unimpaired older adults: Cognitive assessments provide no additional utility beyond demographic and genetic factors.

Alzheimer's & dementia : the journal of the Alzheimer's Association
BACKGROUND: Integrating non-invasive measures to estimate abnormal amyloid beta accumulation (Aβ+) is key to developing a screening tool for preclinical Alzheimer's disease (AD). The predictive capability of standard neuropsychological tests in estim...

A deep-learning retinal aging biomarker for cognitive decline and incident dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association
INTRODUCTION: The utility of retinal photography-derived aging biomarkers for predicting cognitive decline remains under-explored.

Utilising routinely collected clinical data through time series deep learning to improve identification of bacterial bloodstream infections: a retrospective cohort study.

The Lancet. Digital health
BACKGROUND: Blood cultures are the gold standard for diagnosing bacterial bloodstream infections, but test results are only available 24-48 h after sampling. We aimed to develop and evaluate models using health-care data to predict bloodstream infect...

Predicting Sprint Potential: A Machine Learning Model Based on Blood Metabolite Profiles in Young Male Athletes.

European journal of sport science
This study aims to utilize male blood metabolite signatures for (i) distinguishing between healthy individuals and athletes, thereby optimizing the athlete screening process; and (ii) predicting athletic performance in 100, 200, and 400 m sprints, en...

Predicting psoriasis severity using machine learning: a systematic review.

Clinical and experimental dermatology
BACKGROUND: In dermatology, the applications of machine learning (ML), an artificial intelligence (AI) subset that enables machines to learn from experience, have progressed past the diagnosis and classification of skin lesions. A lack of systematic ...

Machine learning algorithm approach to complete blood count can be used as early predictor of COVID-19 outcome.

Journal of leukocyte biology
Although the SARS-CoV-2 infection has established risk groups, identifying biomarkers for disease outcomes is still crucial to stratify patient risk and enhance clinical management. Optimal efficacy of COVID-19 antiviral medications relies on early a...

Machine learning and metabolomics identify biomarkers associated with the disease extent of ulcerative colitis.

Journal of Crohn's & colitis
BACKGROUND AND AIMS: Ulcerative colitis (UC) is a metabolism-related chronic intestinal inflammatory disease. Disease extent is a key parameter of UC. Using serum metabolic profiling to identify noninvasive biomarkers of disease extent may inform the...

Identification and Validation of Biomarkers in Metabolic Dysfunction-Associated Steatohepatitis Using Machine Learning and Bioinformatics.

Molecular genetics & genomic medicine
BACKGROUND: The incidence of metabolic dysfunction-associated steatohepatitis (MASH) is increasing annually. MASH can progress to cirrhosis and hepatocellular carcinoma. However, the early diagnosis of MASH is challenging.

Machine learning prediction of tau-PET in Alzheimer's disease using plasma, MRI, and clinical data.

Alzheimer's & dementia : the journal of the Alzheimer's Association
INTRODUCTION: Tau positron emission tomography (PET) is a reliable neuroimaging technique for assessing regional load of tau pathology in the brain, but its routine clinical use is limited by cost and accessibility barriers.