AIMC Topic: Biopsy

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Deep learning model for predicting extraprostatic extension of prostate cancer based on H&E-stained biopsy digital images.

Annals of medicine
BACKGROUND: To develop and validate a deep learning pipeline using prostate biopsy H&E slides to predict extraprostatic extension (EPE) in prostate cancer (PCa) patients.

Discovery of tumour indicating morphological changes in benign prostate biopsies through AI.

Scientific reports
Diagnostic needle biopsies that miss clinically significant prostate cancer (PCa) often sample benign tissue near hidden cancers. Such benign samples might still display subtle morphological signs of cancer elsewhere in the prostate. This study exami...

Serological proteomic characterization for monitoring liver fibrosis regression in chronic hepatitis B patients on treatment.

Nature communications
Longitudinal serological proteomic dynamics during antiviral therapy (AVT) in chronic hepatitis B (CHB) patients with liver fibrosis remain poorly characterized. Here, using four-dimensional data-independent acquisition mass spectrometry (4D-DIA-MS),...

Nancy histological index in ulcerative colitis: an interobserver study.

Journal of clinical pathology
The Nancy histological index (NHI) is a measure of disease activity within colorectal biopsies and a predictor of clinical outcome in ulcerative colitis (UC). We measured interobserver agreement (IOA) during NHI scoring of 20 colorectal biopsies in U...

Multimodal deep learning improving the accuracy of pathological diagnoses for membranous nephropathy.

Renal failure
OBJECTIVES: Renal biopsy is the gold standard for the diagnosis of glomerular diseases including membranous nephropathy (MN), however, it faces challenges in accuracy, objectivity, and reproducibility of tissue evaluation. This study aims to develop ...

Development and retrospective validation of an artificial intelligence system for diagnostic assessment of prostate biopsies: study protocol.

BMJ open
INTRODUCTION: Histopathological evaluation of prostate biopsies using the Gleason scoring system is critical for prostate cancer diagnosis and treatment selection. However, grading variability among pathologists can lead to inconsistent assessments, ...

Performance of GPT-4 for automated prostate biopsy decision-making based on mpMRI: a multi-center evidence study.

Military Medical Research
BACKGROUND: Multiparametric magnetic resonance imaging (mpMRI) has significantly advanced prostate cancer (PCa) detection, yet decisions on invasive biopsy with moderate prostate imaging reporting and data system (PI-RADS) scores remain ambiguous.

Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis.

Nature communications
Approximately 40% of patients with rheumatoid arthritis do not respond to individual biologic therapies, while biomarkers predictive of treatment response are lacking. Here we analyse RNA-sequencing (RNA-Seq) of pre-treatment synovial tissue from the...

Deep learning for smartphone-aided detection system of Helicobacter Pylori in gastric biopsy.

Scientific reports
Helicobacter pylori (HP) have chronically infected more than half of the world's population and is a cause of chronic gastritis, peptic ulcers and gastric carcinoma. The manual detection of HP in a glass slide with a microscope is extremely time-cons...

Radiomic 'Stress Test': exploration of a deep learning radiomic model in a high-risk prospective lung nodule cohort.

BMJ open respiratory research
BACKGROUND: Indeterminate pulmonary nodules (IPNs) are commonly biopsied to ascertain a diagnosis of lung cancer, but many are ultimately benign. The Lung Cancer Prediction (LCP) score is a commercially available deep learning radiomic model with str...