AIMC Topic: Carcinoma, Hepatocellular

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Influence of vascular endothelial growth factor and alpha-fetoprotein on hepatocellular carcinoma.

Genetics and molecular research : GMR
We evaluated the influence of the vascular endothelial growth factor (VEGF) -C936T polymorphism on prognosis of hepatocellular carcinoma (HCC), cirrhosis, and hepatitis C virus (HCV) infection. Serum VEGF and alpha-fetoprotein (AFP) levels were deter...

Joint sparse coding based spatial pyramid matching for classification of color medical image.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Although color medical images are important in clinical practice, they are usually converted to grayscale for further processing in pattern recognition, resulting in loss of rich color information. The sparse coding based linear spatial pyramid match...

Discovery of novel diagnostic biomarkers of hepatocellular carcinoma associated with immune infiltration.

Annals of medicine
OBJECTIVE: Diagnosis of hepatocellular carcinoma (HCC) remains challenging for clinicians. Machine learning approaches and big data analyses are viable strategies for identifying HCC diagnostic markers.

Identification and validation of feature genes in hepatocellular carcinoma based on bioinformatics and machine learning: An observational study.

Medicine
The incidence of hepatocellular carcinoma (HCC) has risen significantly in recent years, while current diagnostic and therapeutic approaches remain suboptimal. This study aimed to identify novel biomarkers and therapeutic targets to improve early det...

Developing risk stratification strategies and biomarkers for recurrent hepatocellular carcinoma.

Clinical and translational medicine
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, with high rates of post-resection recurrence posing significant clinical challenges. Early recurrence is largely driven by aggressive tumor biology, while late recurr...

Current Advances in Classification, Prediction and Management of Microvascular Invasion in Hepatocellular Carcinoma.

Journal of cellular and molecular medicine
Liver resection remains the mainstay curative treatment for hepatocellular carcinoma (HCC); however, the recurrence rate is reported to exceed 70% within 5 years after surgery. Microvascular invasion (MVI) has attracted great research interest in the...

Leveraging deep learning to discover interpretable cellular spatial biomarkers for prognostic predictions based on hepatocellular carcinoma histology.

The journal of pathology. Clinical research
The spatial structure of various cell types in the tumour microenvironment (TME) can provide valuable insights into disease progression. However, identifying the spatial organization of diverse cell types that significantly correlates with patient pr...