The subspecialty of cardio-oncology has undergone significant growth in recent years, alongside major advances in the management of both cardiovascular disease and cancer, the leading causes of morbidity and mortality in the United States and many co...
The aim is to present expert-agreed guidelines for the primary prevention of cardiovasculotoxicity of anticancer therapy as part of the Cardioprotection 2025 Consensus of the Russian Society of Cardiology, the Society of Heart Failure Specialists, th...
Current treatment options in oncology
Dec 24, 2025
Improved survival in pediatric oncology has highlighted the growing burden of cancer treatment-related cardiotoxicity among survivors of childhood cancers. While the cardiotoxicity of anthracyclines and chest radiation are well documented as major co...
Cardiotoxicity is the loss of the heart muscle's ability to contract effectively, often due to chemotherapy or radiation therapy. This study uses interpretable machine learning to predict post-chemotherapy cardiotoxicity using radiomics features extr...
BACKGROUND: Early detection of cancer therapy-related cardiac dysfunction (CTRCD) after anthracycline exposure is critically important in minimizing morbidity and mortality. Artificial intelligence models applied to electrocardiograms (ECG-AI) may al...
Drug-induced cardiotoxicity (DICT) is a significant challenge in drug development and public health. DICT can arise from various mechanisms; New Approach Methods (NAMs), including quantitative structure-activity relationships (QSARs), have been exten...
Journal of chemical information and modeling
Mar 27, 2025
Cardiotoxicity refers to the inhibitory effects of drugs on cardiac ion channels. Accurate prediction of cardiotoxicity is crucial yet challenging, as it directly impacts the evaluation of cardiac drug efficacy and safety. Numerous methods have been ...
PURPOSE: The human Ether-a-go-go Related-Gene (hERG) encodes rectifying potassium channels that play a significant role during action potential repolarization of cardiomyocytes. Blockade of the hERG channel by off-target drugs can lead to long QT syn...
IEEE journal of biomedical and health informatics
Mar 6, 2025
Investigating the inhibitory effects of compounds on cardiac ion channels is essential for assessing cardiac drug safety. Consequently, researchers have developed computational models to evaluate combined cardiotoxicity (CCT) on cardiac ion channels....
Circulation. Genomic and precision medicine
Feb 24, 2025
Artificial intelligence is poised to transform cardio-oncology by enabling personalized care for patients with cancer, who are at a heightened risk of cardiovascular disease due to both the disease and its treatments. The rising prevalence of cancer ...
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