AIMC Topic: Cell Differentiation

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A deep learning approach to predict differentiation outcomes in hypothalamic-pituitary organoids.

Communications biology Dec 6, 2024
We use three-dimensional culture systems of human pluripotent stem cells for differentiation into pituitary organoids. Three-dimensional culture is inherently characterized by its ability to induce heterogeneous cell populations, making it difficult ...
Humans Pluripotent Stem Cells Deep Learning Organoids Hypothalamus Cell Differentiation Pituitary Gland
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Effect of laser photobiomodulation combined with hydroxyapatite nanoparticles on the osteogenic differentiation of mesenchymal stem cells using artificial intelligence: An in vitro study.

PloS one Nov 14, 2024
AIM: To evaluate in vitro the effect of laser photobiomodulation (PBM) combined or not with 30-nm hydroxyapatite nanoparticles (HANp), on the osteogenic differentiation of human umbilical cord mesenchymal stem cells (hUC-MSCs) by morphometric analysi...
Low-Level Light Therapy Cells, Cultured Mesenchymal Stem Cells Osteogenesis Humans Nanoparticles Durapatite Artificial Intelligence Cell Survival Cell Differentiation
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Real-time monitoring of single dendritic cell maturation using deep learning-assisted surface-enhanced Raman spectroscopy.

Theranostics Oct 14, 2024
Dynamic real-time detection of dendritic cell (DC) maturation is pivotal for accurately predicting immune system activation, assessing vaccine efficacy, and determining the effectiveness of immunotherapy. The heterogeneity of cells underscores the s...
Neural Networks, Computer Animals Deep Learning Humans Spectrum Analysis, Raman Cell Differentiation Dendritic Cells Gold Single-Cell Analysis
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Deep learning for quantifying spatial patterning and formation process of early differentiated human-induced pluripotent stem cells with micropattern images.

Journal of microscopy Jul 12, 2024
Micropatterning is reliable method for quantifying pluripotency of human-induced pluripotent stem cells (hiPSCs) that differentiate to form a spatial pattern of sorted, ordered and nonoverlapped three germ layers on the micropattern. In this study, w...
Germ Layers Cell Differentiation Deep Learning Induced Pluripotent Stem Cells Image Processing, Computer-Assisted Humans
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MyoFInDer: An AI-Based Tool for Myotube Fusion Index Determination.

Tissue engineering. Part A Jun 27, 2024
The fusion index is a key indicator for quantifying the differentiation of a myoblast population, which is often calculated manually. In addition to being time-consuming, manual quantification is also error prone and subjective. Several software tool...
Humans Artificial Intelligence Muscle Fibers, Skeletal Image Processing, Computer-Assisted Cell Fusion Mice Cell Differentiation Software Animals
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SIMS: A deep-learning label transfer tool for single-cell RNA sequencing analysis.

Cell genomics May 31, 2024
Cell atlases serve as vital references for automating cell labeling in new samples, yet existing classification algorithms struggle with accuracy. Here we introduce SIMS (scalable, interpretable machine learning for single cell), a low-code data-effi...
Single-Cell Analysis Mice Sequence Analysis, RNA Animals Deep Learning Organoids Cell Differentiation Neurons Humans Brain
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Detection of biomagnetic signals from induced pluripotent stem cell-derived cardiomyocytes using deep learning with simulation data.

Scientific reports Mar 27, 2024
The detection of spontaneous magnetic signals can be used for the non-invasive electrophysiological evaluation of induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs). We report that deep learning with a dataset that combines magnetic signa...
Drug Evaluation, Preclinical Isoproterenol Induced Pluripotent Stem Cells Myocytes, Cardiac Mice Animals Cell Differentiation Deep Learning
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Deep Learning Powered Identification of Differentiated Early Mesoderm Cells from Pluripotent Stem Cells.

Cells Mar 18, 2024
Pluripotent stem cells can be differentiated into all three germ-layers including ecto-, endo-, and mesoderm in vitro. However, the early identification and rapid characterization of each germ-layer in response to chemical and physical induction of d...
Animals Germ Layers Cell Differentiation Deep Learning Pluripotent Stem Cells Mice Mesoderm
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Early Predicting Osteogenic Differentiation of Mesenchymal Stem Cells Based on Deep Learning Within One Day.

Annals of biomedical engineering Mar 15, 2024
Osteogenic differentiation of mesenchymal stem cells (MSCs) is proposed to be critical for bone tissue engineering and regenerative medicine. However, the current approach for evaluating osteogenic differentiation mainly involves immunohistochemical ...
Osteogenesis Mesenchymal Stem Cells Deep Learning Cell Differentiation Humans Cells, Cultured Animals Neural Networks, Computer
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A neural network-based model framework for cell-fate decisions and development.

Communications biology Mar 14, 2024
Gene regulatory networks (GRNs) fulfill the essential function of maintaining the stability of cellular differentiation states by sustaining lineage-specific gene expression, while driving the progression of development. However, accounting for the r...
Neural Networks, Computer Gene Regulatory Networks Cell Differentiation
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