AIMC Topic: Cell-Free Nucleic Acids

Clear Filters Showing 1 to 10 of 34 articles

Inflammation-related 5-hydroxymethylation signatures as markers for clinical presentations of coronary artery disease.

Cardiovascular diabetology Jun 23, 2025
BACKGROUND: Coronary angiography remains the gold standard for diagnosing coronary artery disease (CAD), but its invasive nature limits its applicability for widespread screening. Identifying non-invasive molecular markers could improve CAD classific...
Risk Assessment Severity of Illness Index Epigenesis, Genetic Inflammation Reproducibility of Results Aged Male Middle Aged ST Elevation Myocardial Infarction Coronary Artery Disease Inflammation Mediators 5-Methylcytosine DNA Methylation Cell-Free Nucleic Acids Non-ST Elevated Myocardial Infarction Predictive Value of Tests Humans Machine Learning Biomarkers Prognosis Female
View on PubMed DOI

A standardized framework for robust fragmentomic feature extraction from cell-free DNA sequencing data.

Genome biology May 23, 2025
Fragmentomics features of cell-free DNA represent promising non-invasive biomarkers for cancer diagnosis. A lack of systematic evaluation of biases in feature quantification hinders the adoption of such applications. We compare features derived from ...
Cell-Free Nucleic Acids Whole Genome Sequencing High-Throughput Nucleotide Sequencing Humans Machine Learning Software Sequence Analysis, DNA
View on PubMed DOI

Microbiome and fragmentation pattern of blood cell-free DNA and fecal metagenome enhance colorectal cancer micro-dysbiosis and diagnosis analysis: a proof-of-concept study.

mSystems Apr 29, 2025
Colorectal cancer (CRC) is the third most common cancer, and it can be prevented by performing early screening. As a hallmark of cancer, the human microbiome plays important roles in the occurrence and development of CRC. Recently, the blood microbio...
Humans Female Aged Adult Gastrointestinal Microbiome Dysbiosis Cell-Free Nucleic Acids Adenoma Colorectal Neoplasms Male Middle Aged Feces Microbiota Proof of Concept Study Metagenome
View on PubMed DOI

Exploring the potential of cell-free RNA and Pyramid Scene Parsing Network for early preeclampsia screening.

BMC pregnancy and childbirth Apr 14, 2025
BACKGROUND: Circulating cell-free RNA (cfRNA) is gaining recognition as an effective biomarker for the early detection of preeclampsia (PE). However, the current methods for selecting disease-specific biomarkers are often inefficient and typically on...
Early Diagnosis Risk Assessment Case-Control Studies Cell-Free Nucleic Acids Pre-Eclampsia Pregnancy Female Adult Humans Neural Networks, Computer Algorithms Biomarkers
View on PubMed DOI

Transformer-based deep learning for accurate detection of multiple base modifications using single molecule real-time sequencing.

Communications biology Apr 14, 2025
We had previously reported a convolutional neural network (CNN) based approach, called the holistic kinetic model (HK model 1), for detecting 5-methylcytosine (5mC) by single molecule real-time sequencing (Pacific Biosciences). In this study, we cons...
Cell-Free Nucleic Acids Adenine 5-Methylcytosine Humans Liver Neoplasms Neural Networks, Computer Carcinoma, Hepatocellular Deep Learning Sequence Analysis, DNA DNA Methylation
View on PubMed DOI

Artificial intelligence and machine learning in cell-free-DNA-based diagnostics.

Genome research Jan 22, 2025
The discovery of circulating fetal and tumor cell-free DNA (cfDNA) molecules in plasma has opened up tremendous opportunities in noninvasive diagnostics such as the detection of fetal chromosomal aneuploidies and cancers and in posttransplantation mo...
Neoplasms Humans Cell-Free Nucleic Acids Artificial Intelligence High-Throughput Nucleotide Sequencing Machine Learning Liquid Biopsy Female
View on PubMed DOI

An appropriate DNA input for bisulfite conversion reveals LINE-1 and Alu hypermethylation in tissues and circulating cell-free DNA from cancers.

PloS one Dec 30, 2024
The autonomous and active Long-Interspersed Element-1 (LINE-1, L1) and the non-autonomous Alu retrotransposon elements, contributing to 30% of the human genome, are the most abundant repeated sequences. With more than 90% of their sequences being met...
Alu Elements Sulfites Cell-Free Nucleic Acids Male Humans Neoplasms Female DNA Methylation Breast Neoplasms Long Interspersed Nucleotide Elements
View on PubMed DOI

Plasma cell-free RNA signatures of inflammatory syndromes in children.

Proceedings of the National Academy of Sciences of the United States of America Sep 6, 2024
Inflammatory syndromes, including those caused by infection, are a major cause of hospital admissions among children and are often misdiagnosed because of a lack of advanced molecular diagnostic tools. In this study, we explored the utility of circul...
Infant Adolescent Child, Preschool Child Systemic Inflammatory Response Syndrome Inflammation Cell-Free Nucleic Acids Mucocutaneous Lymph Node Syndrome COVID-19 Biomarkers Female Male Humans Machine Learning Diagnosis, Differential Bacterial Infections Virus Diseases
View on PubMed DOI

Detecting pulmonary malignancy against benign nodules using noninvasive cell-free DNA fragmentomics assay.

ESMO open Jul 31, 2024
BACKGROUND: Early screening using low-dose computed tomography (LDCT) can reduce mortality caused by non-small-cell lung cancer. However, ∼25% of the 'suspicious' pulmonary nodules identified by LDCT are later confirmed benign through resection surge...
Humans Machine Learning Tomography, X-Ray Computed Carcinoma, Non-Small-Cell Lung Female Cell-Free Nucleic Acids Aged Multiple Pulmonary Nodules Early Detection of Cancer Male Middle Aged Lung Neoplasms Liquid Biopsy
View on PubMed DOI

Tissue of origin detection for cancer tumor using low-depth cfDNA samples through combination of tumor-specific methylation atlas and genome-wide methylation density in graph convolutional neural networks.

Journal of translational medicine Jul 3, 2024
BACKGROUND: Cell free DNA (cfDNA)-based assays hold great potential in detecting early cancer signals yet determining the tissue-of-origin (TOO) for cancer signals remains a challenging task. Here, we investigated the contribution of a methylation at...
Organ Specificity Neoplasms DNA Methylation Cell-Free Nucleic Acids Genome, Human Humans Neural Networks, Computer Algorithms
View on PubMed DOI
Popular Topics
Recent Journals