AIMC Topic: Cell-Free Nucleic Acids
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Deep learning model integrating cfDNA methylation and fragment size profiles for lung cancer diagnosis.
Scientific reports
Jun 26, 2024
Detecting aberrant cell-free DNA (cfDNA) methylation is a promising strategy for lung cancer diagnosis. In this study, our aim is to identify methylation markers to distinguish patients with lung cancer from healthy individuals. Additionally, we soug...
Prediction of Transcription Factor Binding Sites on Cell-Free DNA Based on Deep Learning.
Journal of chemical information and modeling
May 9, 2024
Transcription factors (TFs) are important regulatory elements for vital cellular activities, and the identification of transcription factor binding sites (TFBS) can help to explore gene regulatory mechanisms. Research studies have proved that cfDNA (...
A Machine learning model for predicting sepsis based on an optimized assay for microbial cell-free DNA sequencing.
Clinica chimica acta; international journal of clinical chemistry
May 4, 2024
OBJECTIVE: To integrate an enhanced molecular diagnostic technique to develop and validate a machine-learning model for diagnosing sepsis.
Machine learning-enhanced noninvasive prenatal testing of monogenic disorders.
Prenatal diagnosis
Apr 30, 2024
OBJECTIVE: Single-nucleotide variants (SNVs) are of great significance in prenatal diagnosis as they are the leading cause of inherited single-gene disorders (SGDs). Identifying SNVs in a non-invasive prenatal screening (NIPS) scenario is particularl...
The role of cell-free DNA biomarkers and patient data in the early prediction of preeclampsia: an artificial intelligence model.
American journal of obstetrics and gynecology
Mar 2, 2024
BACKGROUND: Accurate individualized assessment of preeclampsia risk enables the identification of patients most likely to benefit from initiation of low-dose aspirin at 12 to 16 weeks of gestation when there is evidence for its effectiveness, and ena...
Comprehensive tissue deconvolution of cell-free DNA by deep learning for disease diagnosis and monitoring.
Proceedings of the National Academy of Sciences of the United States of America
Jul 3, 2023
Plasma cell-free DNA (cfDNA) is a noninvasive biomarker for cell death of all organs. Deciphering the tissue origin of cfDNA can reveal abnormal cell death because of diseases, which has great clinical potential in disease detection and monitoring. D...
Prediction model for malignant pulmonary nodules based on cfMeDIP-seq and machine learning.
Cancer science
Jul 21, 2021
Cell-free methylated DNA immunoprecipitation and high-throughput sequencing (cfMeDIP-seq) is a new bisulfite-free technique, which can detect the whole-genome methylation of blood cell-free DNA (cfDNA). Using this technique, we identified differentia...
Utilization of circulating cell-free DNA profiling to guide first-line chemotherapy in advanced lung squamous cell carcinoma.
Theranostics
Jan 1, 2021
Platinum-based chemotherapy is one of treatment mainstay for patients with advanced lung squamous cell carcinoma (LUSC) but it is still a "one-size fits all" approach. Here, we aimed to investigate the predictive and monitoring role of circulating c...
Survival Rate
Male
Middle Aged
Lung Neoplasms
Antineoplastic Combined Chemotherapy Protocols
Treatment Outcome
Cell-Free Nucleic Acids
DNA Copy Number Variations
Prognosis
Female
Carcinoma, Squamous Cell
Aged
Humans
Machine Learning
Gemcitabine
Circulating Tumor DNA
Cisplatin
Paclitaxel
Progression-Free Survival
Deoxycytidine
Circulating Neutrophil Extracellular Traps Signature for Identifying Organ Involvement and Response to Glucocorticoid in Adult-Onset Still's Disease: A Machine Learning Study.
Frontiers in immunology
Nov 9, 2020
Adult-onset Still's disease (AOSD) is an autoinflammatory disease with multisystem involvement. Early identification of patients with severe complications and those refractory to glucocorticoid is crucial to improve therapeutic strategy in AOSD. Exag...
Clinical Significance of Circulating Cardiomyocyte-Specific Cell-Free DNA in Patients With Heart Failure: A Proof-of-Concept Study.
The Canadian journal of cardiology
Oct 19, 2019
We investigated clinical significance of cell-free DNA (cfDNA) in heart failure. This study enrolled 32 heart failure patients and 28 control subjects. Total cfDNA levels were not different between groups (P = 0.343). Bisulfite-digital polymerase cha...
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