AIMC Topic: Cell Line, Tumor

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Computer aided prognosis for cell death categorization and prediction in vivo using quantitative ultrasound and machine learning techniques.

Medical physics Dec 1, 2016
PURPOSE: At present, a one-size-fits-all approach is typically used for cancer therapy in patients. This is mainly because there is no current imaging-based clinical standard for the early assessment and monitoring of cancer treatment response. Here,...
Machine Learning Animals Mice Cell Death Cell Transformation, Neoplastic Fibrosarcoma Diagnosis, Computer-Assisted Ultrasonography Cell Line, Tumor Image Processing, Computer-Assisted
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The co-regulators SRC-1 and SMRT are involved in interleukin-6-induced androgen receptor activation.

European cytokine network Nov 1, 2016
BACKGROUND: The androgen receptor (AR) can be stimulated by interleukin-6 (IL-6) in the absence of androgens to induce prostate cancer progression. The purpose of this study was to investigate whether the co-activator steroid receptor coactivator-1 (...
Humans Nuclear Receptor Coactivator 1 Interleukin-6 Male Prostatic Neoplasms Receptors, Androgen Cell Line, Tumor Nuclear Receptor Co-Repressor 2 Neoplasm Proteins
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Diterpenoid Tanshinones, the extract from Danshen (Radix Salviae Miltiorrhizae) induced apoptosis in nine human cancer cell lines.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Aug 1, 2016
OBJECTIVE: To identify the active anti-tumor constituents in the extract from Danshen (Radix Salviae Miltiorrhizae) and investigate the mechanisms underlying the actions.
Apoptosis Humans Caspase 3 Cell Line, Tumor Abietanes Antineoplastic Agents, Phytogenic Cell Proliferation Poly(ADP-ribose) Polymerases Drugs, Chinese Herbal Salvia miltiorrhiza
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Learning approaches to improve prediction of drug sensitivity in breast cancer patients.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference Aug 1, 2016
Predicting drug response to cancer disease is an important problem in modern clinical oncology that attracted increasing recent attention from various domains such as computational biology, machine learning, and data mining. Cancer patients respond d...
Humans Data Mining Breast Neoplasms Algorithms Drug Resistance, Neoplasm Cell Line, Tumor Female Linear Models Computational Biology Models, Theoretical
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Osteoinductive Activity of DFDBA Materials versus Growth Factors on Gene Expression of MG-63 Cells: An In Vitro Study.

Journal of long-term effects of medical implants Jan 1, 2016
Guided bone regeneration using demineralized freeze-dried bone allograft (DFDBA) and growth factors (GFs) is a current goal in implant dentistry because of their potential osteoinductive abilities. Regarding controversial results, the purpose of this...
Osteogenesis Humans Bone Transplantation Osteoblasts Platelet-Derived Growth Factor Cell Line, Tumor Cell Differentiation Transforming Growth Factor beta
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[Bovine lactoferrin decreases the invasion of Salmonella enterica to HEp-2 cells].

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru Jan 1, 2016
OBJECTIVE: To assess the effect of bovine lactoferrin (bLf) on the invasion of Salmonella enterica ser. Typhimurium to HEp-2 cells.
Humans Animals Cell Line, Tumor Cattle Dose-Response Relationship, Drug Salmonella typhimurium Virulence Lactoferrin
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[Study of FN1 and ZNF438 gene expression negatively regulated by androgen receptor in androgen-independent LNCaP cells].

Zhonghua yi xue za zhi Dec 19, 2015
OBJECTIVE: To verify whether FN1 and ZNF438 are the androgen receptor(AR) target genes in LNCaP-AI cells and investigate the effects of AR exerts on FN1 and ZNF438 gene expression.
Receptors, Androgen Oligonucleotide Array Sequence Analysis Repressor Proteins Androgens Dihydrotestosterone Blotting, Western Prostatic Neoplasms Fibronectins Down-Regulation RNA, Messenger Gene Expression Regulation, Neoplastic Gene Expression Humans Male Cell Line, Tumor
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[Enhanced radiosensitivity of H22 ascitic tumor to 12C6+ ions radiation in ultra-filtration extract mixture from Astragalus mongholicus-treated mice].

Yao xue xue bao = Acta pharmaceutica Sinica Dec 1, 2015
This study was designed to investigate the impact of ultra-filtration extract mixture from Astragals mongholicus (UEMAM) o radiosensitivity of H22 ascitic tumor in mice to 12C6+ ions radiation. The H22 ascitic tumor model was established in mice by i...
Ions Astragalus Plant Cell Cycle Neoplasms, Experimental Radiation Tolerance Plant Extracts Animals Signal Transduction Cell Line, Tumor Apoptosis Mice DNA Damage
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A systematic approach to prioritize drug targets using machine learning, a molecular descriptor-based classification model, and high-throughput screening of plant derived molecules: a case study in oral cancer.

Molecular bioSystems Dec 1, 2015
Systems-biology inspired identification of drug targets and machine learning-based screening of small molecules which modulate their activity have the potential to revolutionize modern drug discovery by complementing conventional methods. To utilize ...
Binding Sites Protein Interaction Mapping Mouth Neoplasms High-Throughput Screening Assays Molecular Conformation ROC Curve Humans Gene Regulatory Networks Machine Learning Protein Binding Gene Expression Regulation, Neoplastic Drug Discovery Computational Biology Antineoplastic Agents, Phytogenic Cell Line, Tumor Receptors, CXCR4 Models, Molecular
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LncRNA ontology: inferring lncRNA functions based on chromatin states and expression patterns.

Oncotarget Nov 24, 2015
Accumulating evidences suggest that long non-coding RNAs (lncRNAs) perform important functions. Genome-wide chromatin-states area rich source of information about cellular state, yielding insights beyond what is typically obtained by transcriptome pr...
Gene Regulatory Networks RNA, Messenger Models, Genetic Hep G2 Cells Neoplasms Gene Expression Profiling Cell Line, Tumor Promoter Regions, Genetic Lysine K562 Cells Histones Cell Line RNA, Long Noncoding HeLa Cells Methylation Humans Algorithms Cells, Cultured Gene Ontology Chromatin Transcription Initiation Site
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