AIMC Topic: Cells, Cultured
Clear Filters Showing 91 to 100 of 157 articles
Leptin Stimulates Prolactin mRNA Expression in the Goldfish Pituitary through a Combination of the PI3K/Akt/mTOR, MKK/pMAPK and MEK/ERK Signalling Pathways.
International journal of molecular sciences
Dec 20, 2017
Leptin actions at the pituitary level have been extensively investigated in mammalian species, but remain insufficiently characterized in lower vertebrates, especially in teleost fish. Prolactin (PRL) is a pituitary hormone of central importance to o...
Inhibitory activity of linarin on osteoclastogenesis through receptor activator of nuclear factor κB ligand-induced NF-κB pathway.
Biochemical and biophysical research communications
Dec 18, 2017
Linarin, a natural flavonoid glycoside widely found in plants, has been reported to possess anti-inflammation, neuroprotection and osteogenic properties. However, its impact on osteoclast remains unclear. In the present study, the effects of linarin ...
: High-Throughput Quantification of Fluorescent Synaptic Protein Puncta by Machine Learning.
eNeuro
Dec 6, 2017
Synapse formation analyses can be performed by imaging and quantifying fluorescent signals of synaptic markers. Traditionally, these analyses are done using simple or multiple thresholding and segmentation approaches or by labor-intensive manual anal...
The role of neuron-glia interactions in the emergence of ultra-slow oscillations.
Biological cybernetics
Nov 11, 2017
Ultra-slow cortical oscillatory activity of 1-100 mHz has been recorded in human by electroencephalography and in dissociated cultures of cortical rat neurons, but the underlying mechanisms remain to be elucidated. This study presents a computational...
Structural characterization and osteogenic bioactivity of a sulfated polysaccharide from pacific abalone (Haliotis discus hannai Ino).
Carbohydrate polymers
Nov 6, 2017
Bone morphogenic protein-2 (BMP-2) is known to promote osteogenesis. To find novel adjuvants to enhance the activity of BMP-2, the present study investigated the structure BMP-2-induced osteogenic activity of a water-soluble polysaccharide from the g...
A Machine Learning Assisted, Label-free, Non-invasive Approach for Somatic Reprogramming in Induced Pluripotent Stem Cell Colony Formation Detection and Prediction.
Scientific reports
Oct 18, 2017
During cellular reprogramming, the mesenchymal-to-epithelial transition is accompanied by changes in morphology, which occur prior to iPSC colony formation. The current approach for detecting morphological changes associated with reprogramming purely...
Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification.
Stem cell reports
Oct 12, 2017
Accurately predicting cardioactive effects of new molecular entities for therapeutics remains a daunting challenge. Immense research effort has been focused toward creating new screening platforms that utilize human pluripotent stem cell (hPSC)-deriv...
Nano-topography Enhances Communication in Neural Cells Networks.
Scientific reports
Aug 29, 2017
Neural cells are the smallest building blocks of the central and peripheral nervous systems. Information in neural networks and cell-substrate interactions have been heretofore studied separately. Understanding whether surface nano-topography can dir...
and cell-based analyses reveal strong divergence between prediction and observation of T-cell-recognized tumor antigen T-cell epitopes.
The Journal of biological chemistry
May 23, 2017
Tumor exomes provide comprehensive information on mutated, overexpressed genes and aberrant splicing, which can be exploited for personalized cancer immunotherapy. Of particular interest are mutated tumor antigen T-cell epitopes, because neoepitope-s...
Humans
Models, Immunological
Protein Refolding
T-Lymphocytes, Cytotoxic
Expert Systems
Oligopeptides
Vaccines, Synthetic
Animals
Immunogenicity, Vaccine
Membrane Proteins
Peptide Fragments
Artificial Intelligence
Computational Biology
Mice, Transgenic
Neoplasm Proteins
Epitopes
Cells, Cultured
Cancer Vaccines
Mice, Knockout
Melanoma
Antigens, Neoplasm
HLA-A2 Antigen
Reproducibility of Results
Protein Stability
Sparse and Specific Coding during Information Transmission between Co-cultured Dentate Gyrus and CA3 Hippocampal Networks.
Frontiers in neural circuits
Mar 6, 2017
To better understand encoding and decoding of stimulus information in two specific hippocampal sub-regions, we isolated and co-cultured rat primary dentate gyrus (DG) and CA3 neurons within a two-chamber device with axonal connectivity via micro-tunn...
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