AIMC Topic: Cerebral Cortex

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Inhibition facilitates direction selectivity in a noisy cortical environment.

Journal of computational neuroscience
In a broad class of models, direction selectivity in primary visual cortical neurons arises from the linear summation of spatially offset and temporally lagged inputs combined with a spike threshold. Here, we characterize the robustness of this class...

Feedforward Categorization on AER Motion Events Using Cortex-Like Features in a Spiking Neural Network.

IEEE transactions on neural networks and learning systems
This paper introduces an event-driven feedforward categorization system, which takes data from a temporal contrast address event representation (AER) sensor. The proposed system extracts bio-inspired cortex-like features and discriminates different p...

Deep learning-based cell type profiles reveal signatures of Alzheimer's disease resilience and resistance.

Brain : a journal of neurology
Neurological disorders result from the complex and poorly understood contributions of many cell types. It is therefore essential to uncover mechanisms behind these disorders and identify specific therapeutic targets. Single-nucleus technologies have ...

Abnormalities of brain dynamics based on large-scale cortical network modeling in autism spectrum disorder.

Neural networks : the official journal of the International Neural Network Society
Synaptic increase is a common phenomenon in the brain of autism spectrum disorder (ASD). However, the impact of increased synapses on the neurophysiological activity of ASD remains unclear. To address this, we propose a large-scale cortical network m...

Cortical-subcortical neural networks for motor learning and storing sequence memory.

Neural networks : the official journal of the International Neural Network Society
Motor sequence learning relies on the synergistic collaboration of multiple brain regions. However, most existing models for motor sequence learning primarily focus on functional-level analyses of sequence memory mechanisms, providing limited neuroph...

Exploring the Architectural Biases of the Cortical Microcircuit.

Neural computation
The cortex plays a crucial role in various perceptual and cognitive functions, driven by its basic unit, the canonical cortical microcircuit. Yet, we remain short of a framework that definitively explains the structure-function relationships of this ...

Cortical myelin mapping in antipsychotic medication-naïve, first-episode psychosis patients.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
While white matter myelin primarily functions to accelerate conduction velocity and has been extensively studied in schizophrenia-spectrum disorders (SSD), less is known about the role of gray matter myelin in SSD. Cortical myelination occurs mostly ...

Global, mesoscale and local investigation into resting state fMRI brain network attributes of sleep quality.

International journal of psychophysiology : official journal of the International Organization of Psychophysiology
Poor sleep quality has been found to be associated with functional abnormalities in a few regions of the human brain. However, the brain is a dynamic network cooperation system, and it is necessary to study the relationship between sleep quality and ...

Altered cerebral functional activity and its associated genetic profiles underlying chronic insomnia disorder before and after treatment.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
OBJECTIVES: The resting-state cerebral functional activity underlying chronic insomnia disorder (CID) remains inconsistent, and the effects of pharmacotherapy on such activity are unclear.

Evolution of Cortical Lesions and Function-Specific Cognitive Decline in People With Multiple Sclerosis.

Neurology
BACKGROUND AND OBJECTIVES: Cortical lesions in multiple sclerosis (MS) severely affect cognition, but their longitudinal evolution and impact on specific cognitive functions remain understudied. This study investigates the evolution of function-speci...