AIMC Topic: Cholesterol
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In silico prediction of blood cholesterol levels from genotype data.
PloS one
Feb 10, 2020
In this work we present a framework for blood cholesterol levels prediction from genotype data. The predictor is based on an algorithm for cholesterol metabolism simulation available in literature, implemented and optimized by our group in the R lang...
Generalized Pharmacometric Modeling, a Novel Paradigm for Integrating Machine Learning Algorithms: A Case Study of Metabolomic Biomarkers.
Clinical pharmacology and therapeutics
Jan 28, 2020
There is an unmet need for identifying innovative machine learning (ML) strategies to improve drug treatment regimens and therapeutic outcomes. We investigate Generalized Pharmacometric Modeling (GPM), a novel paradigm that integrates ML algorithms w...
Unsupervised Machine Learning for Analysis of Phase Separation in Ternary Lipid Mixture.
Journal of chemical theory and computation
Oct 7, 2019
Phase separation in mixed lipid systems has been extensively studied both experimentally and theoretically because of its biological importance. A detailed description of such complex systems undoubtedly requires novel mathematical frameworks that ar...
Cholecalciferol, Ergosterol, and Cholesterol Enhance the Antibiotic Activity of Drugs.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
May 24, 2019
UNLABELLED: Background: This is the first report demonstrating the antibiotic-modifying activity of cholecalciferol.
Predictive Estimates of Risks Associated with Type 2 Diabetes Mellitus on the Basis of Biochemical Biomarkers and Derived Time-Dependent Parameters.
Journal of computational biology : a journal of computational molecular cell biology
Apr 17, 2019
The Role of GDF-15 in Heart Failure Patients With Chronic Kidney Disease.
The Canadian journal of cardiology
Dec 26, 2018
BACKGROUND: Growth differentiation factor-15 (GDF-15) is a stress-inducible cytokine and member of the transforming growth factor-β cytokine superfamily that refines prognostic assessment in subgroups of patients with heart failure (HF). We evaluated...
Sex Factors
Heart-Assist Devices
Natriuretic Peptide, Brain
Angiotensin Receptor Antagonists
Biomarkers
Heart Transplantation
Humans
Glomerular Filtration Rate
Blood Pressure
Middle Aged
Female
Proportional Hazards Models
Angiotensin-Converting Enzyme Inhibitors
Follow-Up Studies
Cholesterol
Systole
Renal Insufficiency, Chronic
Male
Growth Differentiation Factor 15
Sodium
Heart Failure, Systolic
Effect of potential probiotic Leuconostoc mesenteroides FB111 in prevention of cholesterol absorption by modulating NPC1L1/PPARα/SREBP-2 pathways in epithelial Caco-2 cells.
International microbiology : the official journal of the Spanish Society for Microbiology
Dec 5, 2018
Mustard kimchi consumption reduces cholesterol levels in rats. To identify lactic acid bacteria (LAB) in kimchi which exert this effect, 20 LAB isolates were evaluated for cholesterol reduction in an in vitro screen. The FB111 strain showed the highe...
A case of apolipoprotein A-I deficiency due to carboxyl-terminal truncation.
Journal of clinical lipidology
Dec 29, 2017
Apolipoprotein A-I deficiency is a rare metabolic disease characterized by an impaired reverse cholesterol transport system resulting in excessive cholesterol accumulation. Here, we discuss a case of apolipoprotein A-I deficiency caused by a carboxyl...
Cholesterol imprinted composite membranes for selective cholesterol recognition from intestinal mimicking solution.
Colloids and surfaces. B, Biointerfaces
Dec 27, 2017
Molecularly imprinted polymers which have been extensively investigated as selective adsorbents were constructed using a template molecule during the polymerization to gain template-specific cavities. In this study, we prepared cholesterol imprinted ...
Nano-biotinylated liposome-based immunoassay for the ultrasensitive detection of protein biomarker in urine.
Talanta
Nov 21, 2017
With the development of proteomics and the continuous discovery of biomarkers of trace proteins, it is important to accurately quantify low abundance protein, especially in urine for clinical diagnostics. In this paper, we reported a novel nano-bioti...
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