American journal of Alzheimer's disease and other dementias
40087144
White matter hyperintensity (WMH) is associated with cognitive impairment. In this study, 79 patients with WMH from hospital 1 were randomly divided into a training set (62 patients) and an internal validation set (17 patients). In addition, 29 WMH p...
International journal of molecular sciences
40076571
Diabetes-related cognitive impairment (DCI) is a severe complication of type 2 diabetes mellitus (T2DM), with limited understanding of its molecular mechanisms hindering effective therapeutic development. This study identified SERPINA3 as a potential...
Detection of Alzheimer's Disease (AD) is critical for successful diagnosis and treatment, involving the common practice of screening for Mild Cognitive Impairment (MCI). However, the progressive nature of AD makes it challenging to identify its causa...
BACKGROUND: Early prediction of progression in dementia is of major importance for providing patients with adequate clinical care, with considerable impact on the organization of the whole healthcare system.
BACKGROUND: Cognitive impairment and depressive symptoms are prevalent and closely interrelated mental health issues in the elderly. Traditional methods for identifying depressive symptoms in this population often lack effectiveness. Machine learning...
An interpretable machine learning (ML) framework is introduced to enhance the diagnosis of Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) by ensuring robustness of the ML models' interpretations. The dataset used comprises volumetric me...
Cognitive impairment in cerebral small vessel disease (CSVD) progresses subtly but carries significant clinical consequences, necessitating effective diagnostic tools. This study developed and validated predictive models for CSVD-related cognitive im...
BACKGROUND: Dementia is a multifaceted disorder that affects cognitive function, necessitating accurate diagnosis for effective management and treatment. Although the Mini-Mental State Examination (MMSE) is widely used to assess cognitive impairment,...
BMC medical informatics and decision making
40050853
BACKGROUND: Dementia is a neurological syndrome marked by cognitive decline. Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the common forms of dementia, each with distinct progression patterns. Early and accurate diagnosis of dementi...
The international journal of neuropsychopharmacology
40087981
BACKGROUND: The global prevalence of dementia is significantly increasing. Early detection and prevention strategies, particularly for mild cognitive impairment (MCI), are crucial but currently hindered by the lack of established biomarkers. Here, we...