AIMC Topic: Disease Models, Animal

Clear Filters Showing 111 to 120 of 311 articles

Bridging AI development with clinical relevance-A scoping review of skin cancer models since CLEAR Derm. Where to next?

The Australasian journal of dermatology Dec 25, 2023
Humans Artificial Intelligence Skin Neoplasms Animals Disease Models, Animal Clinical Relevance
View on PubMed DOI

MASP-2 deficiency does not prevent the progression of diabetic kidney disease in a mouse model of type 1 diabetes.

Scandinavian journal of immunology Dec 25, 2023
Mannan-binding lectin (MBL) initiates the lectin pathway of complement and has been linked to albuminuria and mortality in diabetes. We hypothesize that MBL-associated serine protease 2 (MASP-2) deficiency will protect against diabetes-induced kidney...
Disease Models, Animal Mice, Inbred C57BL Mannose-Binding Protein-Associated Serine Proteases Mice Albuminuria Mice, Knockout Diabetic Nephropathies Animals Diabetes Mellitus, Type 1 Cystatin C Male Diabetes Mellitus, Experimental Disease Progression
View on PubMed DOI

Discovery of a structural class of antibiotics with explainable deep learning.

Nature Dec 20, 2023
The discovery of novel structural classes of antibiotics is urgently needed to address the ongoing antibiotic resistance crisis. Deep learning approaches have aided in exploring chemical spaces; these typically use black box models and do not provide...
Vancomycin-Resistant Enterococci Animals Methicillin-Resistant Staphylococcus aureus Drug Discovery Skin Neural Networks, Computer Deep Learning Staphylococcus aureus Staphylococcal Infections Algorithms Disease Models, Animal Anti-Bacterial Agents Microbial Sensitivity Tests Mice Humans
View on PubMed DOI

What is the impact of intraperitoneal surfactant administration against postoperative intraabdominal adhesion formation? an experimental study.

Turkish journal of medical sciences Nov 25, 2023
BACKGROUND/AIM: Surfactant is a surface-active substance that, in addition to its detergent effect, also has effects that reduce inflammation and fibrosis. Because of these effects, it was aimed herein to investigate the effect of intraperitoneal sur...
Postoperative Complications Rats, Wistar Rats Female Animals Injections, Intraperitoneal Disease Models, Animal Uterus Tissue Adhesions Surface-Active Agents
View on PubMed DOI

Preclinical efficacy of a cell division protein candidate gonococcal vaccine identified by artificial intelligence.

mBio Oct 31, 2023
Vaccines to curb the global spread of multidrug-resistant gonorrhea are urgently needed. Here, 26 vaccine candidates identified by an artificial intelligence-driven platform (Efficacy Discriminative Educated Network[EDEN]) were screened for efficacy ...
Gonorrhea Antibodies, Bacterial Vagina Disease Models, Animal Bacterial Proteins Neisseria gonorrhoeae Antigens, Bacterial Cell Division Bacterial Vaccines Artificial Intelligence Female Animals Mice
View on PubMed DOI

Embryonic cranial cartilage defects in the Fgfr3 mouse model of achondroplasia.

Anatomical record (Hoboken, N.J. : 2007) Sep 25, 2023
Achondroplasia, the most common chondrodysplasia in humans, is caused by one of two gain of function mutations localized in the transmembrane domain of fibroblast growth factor receptor 3 (FGFR3) leading to constitutive activation of FGFR3 and subseq...
Animals Mice Cartilage Skull X-Ray Microtomography Achondroplasia Disease Models, Animal Receptor, Fibroblast Growth Factor, Type 3 Mutation
View on PubMed DOI

Quantifying acute kidney injury in an Ischaemia-Reperfusion Injury mouse model using deep-learning-based semantic segmentation in histology.

Biology open Sep 21, 2023
This study focuses on ischaemia-reperfusion injury (IRI) in kidneys, a cause of acute kidney injury (AKI) and end-stage kidney disease (ESKD). Traditional kidney damage assessment methods are semi-quantitative and subjective. This study aims to use a...
Semantics Necrosis Mice Disease Models, Animal Reperfusion Injury Acute Kidney Injury Animals Deep Learning
View on PubMed DOI

Combining electromyographic and electrical impedance data sets through machine learning: A study in D2-mdx and wild-type mice.

Muscle & nerve Sep 2, 2023
INTRODUCTION/AIMS: Needle impedance-electromyography (iEMG) assesses the active and passive electrical properties of muscles concurrently by using a novel needle with six electrodes, two for EMG and four for electrical impedance myography (EIM). Here...
Mice Disease Models, Animal Muscle, Skeletal Machine Learning Muscular Dystrophies Electromyography Animals Mice, Inbred mdx Electric Impedance Male
View on PubMed DOI

Deep Learning-Based Image Analysis of Liver Steatosis in Mouse Models.

The American journal of pathology May 24, 2023
The incidence of nonalcoholic fatty liver disease is a continuously growing health problem worldwide, along with obesity. Therefore, novel methods to both efficiently study the manifestation of nonalcoholic fatty liver disease and to analyze drug eff...
Disease Models, Animal Liver Non-alcoholic Fatty Liver Disease Animals Deep Learning Neural Networks, Computer Mice Algorithms
View on PubMed DOI

A fully automated micro‑CT deep learning approach for precision preclinical investigation of lung fibrosis progression and response to therapy.

Respiratory research May 9, 2023
Micro-computed tomography (µCT)-based imaging plays a key role in monitoring disease progression and response to candidate drugs in various animal models of human disease, but manual image processing is still highly time-consuming and prone to operat...
Humans Reproducibility of Results Animals Deep Learning Mice Disease Models, Animal Bleomycin Pulmonary Fibrosis X-Ray Microtomography
View on PubMed DOI
Popular Topics
Recent Journals