AIMC Topic: DNA Methylation
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5-Hydroxymethylcytosine signatures as diagnostic biomarkers for septic cardiomyopathy.
Scientific reports
Jul 4, 2025
At present, there are currently no molecular biomarkers for the early diagnosis of sepsis cardiomyopathy (SCM) in clinical practice. This study focuses on an in-depth examination of the DNA hydroxymethylation profiles within plasma extracellular vesi...
Multiomic integration reveals subtype-specific predictors of neoadjuvant treatment response in breast cancer.
Science advances
Jul 4, 2025
Neoadjuvant therapy has been widely used in breast cancer, but treatment response varies among individuals. We conducted multiomic profiling on tumor samples from 149 Chinese patients with breast cancer across ERHER2, ERHER2, and ERHER2 subtypes, cat...
A review of the use of tumour DNA methylation for breast cancer subtyping and prediction of outcomes.
Clinical epigenetics
Jul 2, 2025
DNA methylation in breast tumours has been extensively studied and has provided valuable insights into the clinical heterogeneity of breast cancer. In this review, we summarise the current literature that has used DNA methylation markers to subtype b...
RareNet: a deep learning model for rare cancer diagnosis.
Scientific reports
Jul 2, 2025
Although significant advances have been made in the early detection of many cancers, challenges remain in the early diagnosis of rare cancers, including Wilms tumor, Clear Cell Sarcoma of the Kidney, Neuroblastoma, Osteosarcoma, and Acute Myeloid Leu...
Identifying ovarian cancer with machine learning DNA methylation pattern analysis.
Scientific reports
Jul 1, 2025
The majority of patients with epithelial ovarian cancer (EOC) continue to be diagnosed at an advanced stage despite great advances in this disease treatment. To impact overall survival, we need better methods of EOC early diagnosis. We performed a ca...
Inflammation-related 5-hydroxymethylation signatures as markers for clinical presentations of coronary artery disease.
Cardiovascular diabetology
Jun 23, 2025
BACKGROUND: Coronary angiography remains the gold standard for diagnosing coronary artery disease (CAD), but its invasive nature limits its applicability for widespread screening. Identifying non-invasive molecular markers could improve CAD classific...
5-Methylcytosine
Predictive Value of Tests
ST Elevation Myocardial Infarction
Coronary Artery Disease
Inflammation Mediators
DNA Methylation
Cell-Free Nucleic Acids
Non-ST Elevated Myocardial Infarction
Aged
Male
Biomarkers
Risk Assessment
Middle Aged
Prognosis
Severity of Illness Index
Humans
Female
Epigenesis, Genetic
Machine Learning
Reproducibility of Results
Inflammation
DeepRice6mA: A convolutional neural network approach for 6mA site prediction in the rice Genome.
PloS one
Jun 18, 2025
As one of the most critical post-replication modifications, N6-methylation (6mA) at adenine residue plays an important role in a variety of biological functions. Existing computational methods for identifying 6mA sites across large genomic regions te...
Artificial Intelligence in cancer epigenomics: a review on advances in pan-cancer detection and precision medicine.
Epigenetics & chromatin
Jun 14, 2025
DNA methylation is a fundamental epigenetic modification that regulates gene expression and maintains genomic stability. Consequently, DNA methylation remains a key biomarker in cancer research, playing a vital role in diagnosis, prognosis, and tailo...
Plasma and Urine Circulating Tumor DNA Methylation Profiles for Non-Invasive Pancreatic Ductal Adenocarcinoma Detection: Significant Findings in Plasma Only.
International journal of molecular sciences
May 22, 2025
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with limited treatment options, and early detection remains challenging due to the lack of reliable non-invasive biomarkers. This study investigated plasma and urine circulating tumor deo...
Metabolic profiles in laryngeal cancer defined two distinct molecular subtypes with divergent prognoses.
Frontiers in immunology
May 22, 2025
BACKGROUND: Laryngeal cancer (LCA) is the second most common type of head and neck malignancy, characterized by high recurrence rates and poor overall survival (OS). However, progress in curing LCA through molecular-targeted diagnostics and therapies...
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