AIMC Topic: Drugs, Chinese Herbal

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Fast and accurate discrimination analysis of Angelicae Pubescentis Radix using non-targeted analytical profiles images and two-dimensional convolution neural network.

Journal of chromatography. A
This study developed an effective approach for discriminating geographical origins of Duhuo samples using non-targeted UPLC chromatograms and UV-Vis spectrogram images combined with a two-dimensional convolution neural network (2D-CNN). For compariso...

Online detection of Q-marker concentrations in the Xuefu Zhuyu oral liquid extraction process using a multi-source cross-scale NIR attention fusion neural network.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Near-infrared (NIR) spectroscopy, a pivotal tool within process analytical technology (PAT), offers significant potential for real-time monitoring of quality marker (Q-Marker) concentrations in traditional Chinese medicine (TCM) extracts to ensure ba...

Unveiling mitochondrial-targeting compounds in Qishenyiqi dropping pills for heart failure treatment: An integrative UHPLC-QTOF MS and high-content imaging strategy.

Journal of pharmaceutical and biomedical analysis
Mitochondrial dysfunction, a central pathogenic driver of heart failure (HF), underscores the therapeutic imperative to preserve mitochondrial homeostasis. Qishenyiqi dropping pills (QSYQ), a clinically validated traditional Chinese formulation, exhi...

Precision Strike Strategy for Liver Diseases Trilogy with Xiao-Chai-Hu Decoction: A Meta-Analysis with Machine Learning.

Phytomedicine : international journal of phytotherapy and phytopharmacology
BACKGROUND AND PURPOSE: The progression from hepatitis to liver fibrosis (LF) and ultimately to hepatic carcinoma (HCC) represents the advanced stages of various liver diseases. Currently, no universal treatment effectively addresses all three condit...

Bioactive components of Jiedu Sangen decoction against colorectal cancer: A novel and comprehensive research strategy for natural drug development.

Phytomedicine : international journal of phytotherapy and phytopharmacology
BACKGROUND: Jiedu Sangen Decoction (JSD) is widely used in the treatment of colorectal cancer (CRC) patients in southern China due to its good clinical efficacy, but the effective active ingredients are still unknown.

Gui-Pi-Tang Defers Skeletal Muscle and Cardiac Muscle Aging by Promoting Mitochondrial Remodeling.

Drug design, development and therapy
PURPOSE: To determine whether Gui-Pi-Tang (GPT) has protective effects on skeletal muscle and cardiac muscle in aged mice.

Coptidis rhizoma and berberine as anti-cancer drugs: A 10-year updates and future perspectives.

Pharmacological research
Cancer continues to be among the most substantial health challenges globally. Among various natural compounds, berberine, an isoquinoline alkaloid obtained from Coptidis Rhizoma, has garnered considerable attention for its broad-spectrum biological a...

ShenJiaoLingCao decoction ameliorates cyclophosphamide-induced splenic injury and immunosuppression via the inhibition of MEK/ERK signaling pathway activity and modulation of amino acid metabolism.

Journal of ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE: ShenJiaoLingCao Decoction (SJLCD) is derived from the classic Chinese medicine prescription, which consists of ten kinds of herbs. In China, SJLCD has been used as an immunomodulator in clinical practice for more than ...

Traditional Chinese medicine as a promising choice for future control of PEDV.

Virus research
Porcine epidemic diarrhea virus (PEDV) is the major agent of the recent outbreaks of diarrhea in piglets, which has caused huge economic losses to the global swine industry. Since traditional vaccine strategies cannot provide complete protection for ...

Therapeutic effect and concomitant toxicity of hydrargyrum chloratum compositum on chronic difficult-to-heal wounds in rats.

Journal of ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE: Hydrargyrum chloratum compositum(Hcc) is a traditional Chinese medicine for external use, with the efficacy of 'transforming corrosion and pulling out toxins, removing corrosion and regenerating muscles'. The main comp...