AIMC Topic: Fatty Liver

Clear Filters Showing 1 to 10 of 94 articles

Therapeutic horizons in metabolic dysfunction-associated steatohepatitis.

The Journal of clinical investigation Jul 1, 2025
Metabolic dysfunction-associated steatohepatitis (MASH), the progressive inflammatory form of MASLD, is now a leading cause of chronic liver disease worldwide. Driven by obesity and type 2 diabetes, MASH significantly increases the risk of cirrhosis,...
Diabetes Mellitus, Type 2 Fatty Liver Liver Cirrhosis Non-alcoholic Fatty Liver Disease Incretins Humans Animals
View on PubMed DOI

The utility of an artificial intelligence model based on decision tree and evolution algorithm to evaluate steatotic liver disease in a primary care setting.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas Jun 16, 2025
Many ways of classifying steatotic liver disease (SLD) with metabolic conditions have been proposed. Thus, SLD-related variables were verified using a decision tree. We tested if the suggested components of the actual classification (metabolic dysfun...
Middle Aged Humans Primary Health Care Female Fatty Liver Metabolic Syndrome Young Adult Risk Factors Body Mass Index Decision Trees Aged Adult Artificial Intelligence Cross-Sectional Studies Algorithms Male
View on PubMed DOI

CDKN1A and EGR1 are key genes for endoplasmic reticulum stress-induced ferroptosis in MASH.

Free radical biology & medicine May 23, 2025
Metabolic dysfunction-associated steatohepatitis (MASH) is a complex liver disease whose pathogenesis involving endoplasmic reticulum (ER) stress and ferroptosis. However, key regulatory genes remain poorly understood, hindering the development of ef...
Animals Male Mice Fatty Liver Disease Models, Animal Humans Endoplasmic Reticulum Stress Diet, High-Fat Phenylenediamines Early Growth Response Protein 1 Ferroptosis Hep G2 Cells Non-alcoholic Fatty Liver Disease Cyclin-Dependent Kinase Inhibitor p21 Gene Expression Regulation Mice, Inbred C57BL Liver
View on PubMed DOI

Meta-analysis of shotgun sequencing of gut microbiota in obese children with MASLD or MASH.

Gut microbes May 21, 2025
Alterations in the gut microbiome affect the development and severity of metabolic dysfunction-associated steatotic liver disease (MASLD) or metabolic dysfunction-associated steatohepatitis (MASH). We analyzed microbiomes of obese children with and w...
Bacteria Fatty Liver Pediatric Obesity Gastrointestinal Microbiome Male Adolescent Child Feces Obesity Metagenomics Shotgun Sequencing Humans Female
View on PubMed DOI

Unsupervised Test-Time Adaptation for Hepatic Steatosis Grading Using Ultrasound B-Mode Images.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control May 7, 2025
Ultrasound (US) is considered a key modality for the clinical assessment of hepatic steatosis (i.e., fatty liver) due to its noninvasiveness and availability. Deep learning methods have attracted considerable interest in this field, as they are capab...
Liver Middle Aged Algorithms Unsupervised Machine Learning Deep Learning Humans Female Image Interpretation, Computer-Assisted Ultrasonography Neural Networks, Computer Male Fatty Liver
View on PubMed DOI

Unraveling MASLD: The Role of Gut Microbiota, Dietary Modulation, and AI-Driven Lifestyle Interventions.

Nutrients May 4, 2025
Gut microbiota has a crucial role in the pathophysiology of metabolic-associated steatotic liver disease (MASLD), influencing various metabolic mechanisms and contributing to the development of the disease. Dietary interventions targeting gut microbi...
Artificial Intelligence Precision Medicine Diet Fatty Liver Life Style Gastrointestinal Microbiome Non-alcoholic Fatty Liver Disease Humans
View on PubMed DOI

Identifying disease progression biomarkers in metabolic associated steatotic liver disease (MASLD) through weighted gene co-expression network analysis and machine learning.

Journal of translational medicine Apr 24, 2025
BACKGROUND: Metabolic Associated Steatotic Liver Disease (MASLD), encompassing conditions simple liver steatosis (MAFL) and metabolic associated steatohepatitis (MASH), is the most prevalent chronic liver disease. Currently, the management of MASLD i...
Protein Interaction Maps Animals Gene Expression Regulation Humans Disease Progression Gene Ontology Gene Regulatory Networks Machine Learning Gene Expression Profiling Fatty Liver Biomarkers ROC Curve Nomograms Reproducibility of Results
View on PubMed DOI

Machine learning-based disease risk stratification and prediction of metabolic dysfunction-associated fatty liver disease using vibration-controlled transient elastography: Result from NHANES 2021-2023.

BMC gastroenterology Apr 14, 2025
BACKGROUND: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a common chronic liver disease and represents a significant public health issue. Nevertheless, current risk stratification methods remain inadequate. The study aimed to use m...
Humans Female Nutrition Surveys Machine Learning Risk Factors Non-alcoholic Fatty Liver Disease Middle Aged Adult Vibration Risk Assessment Male Elasticity Imaging Techniques ROC Curve Fatty Liver
View on PubMed DOI

AI-enabled opportunistic measurement of liver steatosis in coronary artery calcium scans predicts cardiovascular events and all-cause mortality: an AI-CVD study within the Multi-Ethnic Study of Atherosclerosis (MESA).

BMJ open diabetes research & care Apr 12, 2025
INTRODUCTION: About one-third of adults in the USA have some grade of hepatic steatosis. Coronary artery calcium (CAC) scans contain more information than currently reported. We previously reported new artificial intelligence (AI) algorithms applied ...
Coronary Artery Disease Atherosclerosis Calcium Ethnicity Coronary Vessels Vascular Calcification Middle Aged Fatty Liver United States Follow-Up Studies Humans Risk Factors Artificial Intelligence Algorithms Aged Prognosis Male Female Cardiovascular Diseases
View on PubMed DOI

Predicting metabolic dysfunction associated steatotic liver disease using explainable machine learning methods.

Scientific reports Apr 11, 2025
Early and accurate identification of patients at high risk of metabolic dysfunction-associated steatotic liver disease (MASLD) is critical to prevent and improve prognosis potentially. We aimed to develop and validate an explainable prediction model ...
Humans Machine Learning Algorithms Fatty Liver Cross-Sectional Studies Female Nutrition Surveys Risk Factors Male Area Under Curve Aged Middle Aged Elasticity Imaging Techniques Adult ROC Curve
View on PubMed DOI
Popular Topics
Recent Journals